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Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL
The Journal of Headache and Pain ( IF 7.4 ) Pub Date : 2019-11-11 , DOI: 10.1186/s10194-019-1052-6
Jingjing Su 1 , Shiyu Ban 2 , Mengxing Wang 2, 3 , Fengchun Hua 4 , Liang Wang 5 , Xin Cheng 5 , Yuping Tang 5 , Houguang Zhou 6 , Yu Zhai 1 , Xiaoxia Du 2 , Jianren Liu 1
Affiliation  

BackgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive functioning requires the dynamic coordination of neural activity over large-scale networks. It remains unclear whether changes in resting-state brain functional network connectivity and regional homogeneities (ReHos) underly the mechanisms of executive dysfunction evident in CADASIL patients.MethodsIn this study, 22 CADASIL patients and 44 matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI). Independent component analysis (ICA) was used to measure functional brain network connectivity, and ReHos were calculated to evaluate local brain activities. We used seed-based functional connectivity (FC) analyses to determine whether dysfunctional areas (as defined by ReHos) exhibited abnormal FC with other brain areas. Relationships among the mean intra-network connectivity z-scores of dysfunctional areas within functional networks, and cognitive scores were evaluated using Pearson correlation analyses.ResultsCompared to the controls, CADASIL patients exhibited decreased intra-network connectivity within the bilateral lingual gyrus (LG) and the right cuneus (CU) (thus within the visual network [VIN)], and within the right precuneus (Pcu), inferior frontal gyrus (IFG), and precentral gyrus (thus within the frontal network [FRN]). Compared to the controls, patients also exhibited significantly lower ReHos in the right precuneus and cuneus (Pcu/CU), visual association cortex, calcarine gyri, posterior cingulate, limbic lobe, and weaker FC between the right Pcu/CU and the bilateral parahippocampal gyrus (PHG), and between the right Pcu/CU and the right postcentral gyrus. Notably, the mean connectivity z-scores of the bilateral LG and the right CU within the VIN were positively associated with compromised attention, calculation and delayed recall as revealed by tests of the various cognitive domains explored by the Mini-Mental State Examination.ConclusionsThe decreases in intra-network connectivity within the VIN and FRN and reduced local brain activity in the posterior parietal area suggest that patients with CADASIL may exhibit dysfunctional visuomotor behaviors (a hallmark of executive function), and that all visual information processing, visuomotor planning, and movement execution may be affected.

中文翻译:

CADASIL 患者静息状态脑功能网络连接性降低和区域同质性差

背景伴有皮质下梗死和白质脑病的常染色体显性遗传脑动脉病 (CADASIL) 主要表现为一系列认知障碍,尤其是在执行领域。执行功能需要神经活动在大规模网络上的动态协调。目前尚不清楚静息状态脑功能网络连接和区域同质性 (ReHos) 的变化是否是 CADASIL 患者明显执行功能障碍的机制的基础。 方法 在这项研究中,22 名 CADASIL 患者和 44 名匹配的健康对照接受静息状态功能磁共振成像(功能磁共振成像)。独立成分分析(ICA)用于测量功能性大脑网络连接,并计算ReHos来评估局部大脑活动。我们使用基于种子的功能连接 (FC) 分析来确定功能障碍区域(由 ReHos 定义)是否与其他大脑区域表现出异常 FC。使用 Pearson 相关分析评估功能网络内功能障碍区域的平均网络内连接 z 分数与认知评分之间的关​​系。 结果与对照组相比,CADASIL 患者双侧舌回 (LG) 和右楔骨 (CU)(因此在视觉网络 [VIN] 内),在右楔前叶(Pcu)内,额下回(IFG)和中央前回(因此在额叶网络 [FRN] 内)。与对照组相比,患者的右侧楔前叶和楔骨 (Pcu/CU)、视觉关联皮层、距状回、后扣带回、边缘叶和右侧 Pcu/CU 与双侧海马旁回 (PHG) 之间以及右侧 Pcu/CU 与右侧中央后回之间的 FC 较弱。值得注意的是,双侧 LG 和 VIN 内右侧 CU 的平均连通性 z 分数与注意力下降、计算和延迟回忆呈正相关,正如小型精神状态检查所探索的各种认知领域的测试所揭示的那样。在 VIN 和 FRN 内的网络内连接以及后顶叶区域局部大脑活动减少表明 CADASIL 患者可能表现出功能失调的视觉运动行为(执行功能的标志),并且所有视觉信息处理、视觉运动规划和运动执行可能会受到影响。右侧 Pcu/CU 与双侧海马旁回 (PHG) 之间以及右侧 Pcu/CU 与右侧中央后回之间的 FC 较弱。值得注意的是,双侧 LG 和 VIN 内右侧 CU 的平均连通性 z 分数与注意力、计算和延迟回忆的受损呈正相关,正如小型精神状态检查所探索的各种认知领域的测试所揭示的那样。在 VIN 和 FRN 内的网络内连接以及后顶叶区域局部大脑活动减少表明 CADASIL 患者可能表现出功能失调的视觉运动行为(执行功能的标志),并且所有视觉信息处理、视觉运动规划和运动执行可能会受到影响。右侧 Pcu/CU 与双侧海马旁回 (PHG) 之间以及右侧 Pcu/CU 与右侧中央后回之间的 FC 较弱。值得注意的是,双侧 LG 和 VIN 内右侧 CU 的平均连通性 z 分数与注意力、计算和延迟回忆的受损呈正相关,正如小型精神状态检查所探索的各种认知领域的测试所揭示的那样。在 VIN 和 FRN 内的网络内连接以及后顶叶区域局部大脑活动减少表明 CADASIL 患者可能表现出功能失调的视觉运动行为(执行功能的标志),并且所有视觉信息处理、视觉运动规划和运动执行可能会受到影响。
更新日期:2019-11-11
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