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Computed tomography-derived area and density of pectoralis muscle associated disease severity and longitudinal changes in chronic obstructive pulmonary disease: a case control study
Respiratory Research ( IF 5.8 ) Pub Date : 2019-10-21 , DOI: 10.1186/s12931-019-1191-y
So Hyeon Bak , Sung Ok Kwon , Seon-Sook Han , Woo Jin Kim

Muscle wasting is associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). The cross-sectional area of skeletal muscles on computed tomography (CT) could serve as a method to evaluate body composition. The present study aimed to determine the ability of CT-derived pectoralis muscle area (PMA) and pectoralis muscle density (PMD) to determine the severity of COPD and change in longitudinal pulmonary function in patients with COPD. A total of 293 participants were enrolled in this study, a whom 222 had undergone at least two spirometry measurements within 3 years after baseline data acquisition. PMA and PMD were measured from a single axial slice of chest CT above the aortic arch at baseline. The emphysema index and bronchial wall thickness were quantitatively assessed in all scans. The generalized linear model was used to determine the correlation between PMA and PMD measurements and pulmonary function. PMA and PMD were significantly associated with baseline lung function and the severity of emphysema (P < 0.05). Patients with the lowest PMA and PMD exhibited significantly more severe airflow obstruction (β = − 0.06; 95% confidence interval: − 0.09 to − 0.03]. PMA was statistically associated with COPD assessment test (CAT) score (P = 0.033). However, PMD did not exhibit statistically significant correlation with either CAT scores or modified Medical Research Council scores (P > 0.05). Furthermore, neither PMA nor PMD were associated with changes in forced expiratory volume in 1 s over a 3-year periods. CT-derived features of the pectoralis muscle may be helpful in predicting disease severity in patients with COPD, but are not necessarily associated with longitudinal changes in lung function.

中文翻译:

计算机体层摄影术得出的胸大肌相关面积和密度与慢性阻塞性肺疾病的严重程度和纵向变化的关系:病例对照研究

肌肉消耗与慢性阻塞性肺疾病(COPD)患者的预后有关。计算机断层扫描(CT)上的骨骼肌横截面积可作为评估人体成分的方法。本研究旨在确定CT衍生的胸大肌面积(PMA)和胸大肌密度(PMD)的能力,以确定COPD患者的COPD严重程度和纵向肺功能的变化。共有293名受试者参加了本研究,其中222名受试者在获得基线数据后的3年内至少进行了两次肺活量测定。PMA和PMD是在基线时从主动脉弓上方的胸部CT的单个轴向切片测得的。在所有扫描中定量评估肺气肿指数和支气管壁厚度。使用广义线性模型确定PMA和PMD测量值与肺功能之间的相关性。PMA和PMD与基线肺功能和肺气肿的严重程度显着相关(P <0.05)。PMA和PMD最低的患者表现出更严重的气流阻塞(β= − 0.06; 95%置信区间:− 0.09至− 0.03]。PMA与COPD评估测试(CAT)评分存在统计学相关性(P = 0.033)。 ,PMD与CAT分数或改良的医学研究理事会分数均无统计学意义(P> 0.05),而且PMA和PMD均与3年内1 s内呼气量的变化无关。胸肌的衍生特征可能有助于预测COPD患者的疾病严重程度,
更新日期:2019-10-21
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