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Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery.
Reproductive Biology and Endocrinology ( IF 4.4 ) Pub Date : 2019-08-09 , DOI: 10.1186/s12958-019-0511-x
Yubin Cao 1, 2 , Zeping Li 1, 2 , Wenyu Jiang 1, 2 , Yan Ling 3 , Haibin Kuang 1, 4
Affiliation  

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.

中文翻译:

外围的Kisspeptin / KISS1R系统的生殖功能。

Kisspeptin及其G蛋白偶联受体KISS1R由于参与青春期的发作和下丘脑-垂体-性腺轴的控制,因此在哺乳动物的繁殖中起关键作用。然而,最近的研究表明下丘脑外吻肽素在生殖功能中的潜在作用。在这里,我们总结了对Kisspeptin / KISS1R在外周生殖系统(包括卵巢,睾丸,子宫和胎盘)中的生理学意义以及Kisspeptin / KISS1R在生殖疾病中的潜在作用的最新进展。对Kisspeptin / KISS1R在周围生殖系统中的表达,功能和潜在分子机制的全面了解将有助于生殖疾病的诊断,治疗和预防。
更新日期:2019-08-09
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