Oxygen consumption after surgery is increased in response to the tissue trauma sustained intra-operatively and the subsequent systemic inflammatory response that ensues. The cardio-respiratory system must match the tissue oxygen and metabolic requirements; otherwise, peri-operative complications may occur. Existing data is several decades old. The primary objective of this feasibility study was to determine the ease of recruiting participants and collecting relevant data to assess the extent and duration of increased oxygen consumption and post-operative complications after major abdominal surgery in contemporaneous times. One hundred patients scheduled for elective colorectal surgery requiring a bowel resection were screened to test specific feasibility criteria relating to ease of recruitment, duration of post-operative stay, ease of data collection, and drop-out rates. A calibrated metabolic cart was used to obtain unblinded pre-operative resting oxygen consumption recordings. The metabolic cart was then used to obtain post-operative oxygen consumption readings on days 1 to 5 as long as the participant remained as an inpatient. At the time of the oxygen consumption reading, a Post-Operative Morbidity Survey score (POMS) was calculated. Feasibility outcomes chosen a priori were that at least one participant would be recruited every 2 weeks from the pre-admission colorectal clinic, at least 10% of potential subjects screened would be enrolled, at least 80% of recruited participants would have a minimum post-operative stay of 2 nights, a minimum of 3 consecutive days of oxygen consumption data would be collected for each subject, at least 8 of 9 POMS score domains would be completed per participant per day and the drop-out rate would be no greater than 10%. We deemed that screening 100 patients would be sufficient to test our feasibility outcomes. Twelve participants completed the protocol. All pre-specified feasibility criteria were met. No increase in post-operative oxygen consumption was observed in this feasibility cohort. The protocol and experiences gained from this feasibility study could be used to plan a larger study to better define changes in post-operative oxygen consumption after major abdominal surgery utilizing current surgical techniques.

中文翻译：

---

一项调查需要肠切除的结直肠手术后术后耗氧量 (POpOC) 的可行性研究

手术后的耗氧量随着术中持续的组织创伤和随之而来的全身炎症反应而增加。心肺系统必须与组织氧气和代谢需求相匹配；否则，可能会出现围手术期并发症。现有数据已有几十年的历史。这项可行性研究的主要目的是确定招募参与者和收集相关数据的难易程度，以评估同期腹部大手术后耗氧量增加和术后并发症的程度和持续时间。对 100 名计划进行需要肠切除的选择性结直肠手术的患者进行筛查，以测试与招募难易程度、术后住院时间、易于数据收集和辍学率。使用校准的代谢推车获得非盲的术前静息耗氧量记录。只要参与者仍然是住院病人，代谢推车就被用来在第 1 天到第 5 天获得术后耗氧量读数。在氧气消耗读数时，计算术后发病率调查评分 (POMS)。先验选择的可行性结果是，每 2 周从入院前结直肠诊所招募至少一名参与者，至少 10% 的筛选潜在受试者将被招募，至少 80% 的招募参与者将至少有手术住院 2 晚，将收集每个受试者至少连续 3 天的耗氧量数据，每位参与者每天至少完成 9 个 POMS 评分域中的 8 个，并且辍学率不超过 10%。我们认为筛选 100 名患者足以测试我们的可行性结果。十二名参与者完成了协议。满足所有预先指定的可行性标准。在这个可行性队列中没有观察到术后耗氧量的增加。从这项可行性研究中获得的方案和经验可用于计划一项更大的研究，以更好地确定利用当前手术技术进行的腹部大手术后术后耗氧量的变化。十二名参与者完成了协议。满足所有预先指定的可行性标准。在这个可行性队列中没有观察到术后耗氧量的增加。从这项可行性研究中获得的方案和经验可用于计划一项更大的研究，以更好地确定利用当前手术技术进行的腹部大手术后术后耗氧量的变化。十二名参与者完成了协议。满足所有预先指定的可行性标准。在这个可行性队列中没有观察到术后耗氧量的增加。从这项可行性研究中获得的方案和经验可用于计划一项更大的研究，以更好地确定利用当前手术技术进行的腹部大手术后术后耗氧量的变化。