当前位置：
X-MOL 学术
›
Lipids Health Dis.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Correlation of triglyceride to high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease among the non-obese Chinese population with normal blood lipid levels: a retrospective cohort research.
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2019-08-09 , DOI: 10.1186/s12944-019-1104-6 Zekai Chen 1, 2 , Hailun Qin 1, 2 , Shaobin Qiu 1, 3 , Guanzhi Chen 4 , Youren Chen 2
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2019-08-09 , DOI: 10.1186/s12944-019-1104-6 Zekai Chen 1, 2 , Hailun Qin 1, 2 , Shaobin Qiu 1, 3 , Guanzhi Chen 4 , Youren Chen 2
Affiliation
BACKGROUND
Although nonalcoholic fatty liver disease (NAFLD) is commonly seen in metabolic abnormalities patients, NAFLD is also occurred in the non-obese individuals. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is considered as a predictive factor of NAFLD. However, it is still difficult to confirm the correlation of TG/HDL-C ratio with NAFLD among non-obese Chinese people with normal blood lipid levels. In our study, it is aimed to analyze the correlation of TG/HDL-C ratio with NAFLD among non-obese Chinese population without dyslipidemia.
METHODS
In the retrospective cohort study, 9838 non-obese subjects who were free of NAFLD were enrolled. NAFLD was diagnosed by ultrasonography.
RESULTS
During the median follow-up period of 2.9 years, cumulative incidence of NAFLD in non-obesity individuals was 8.69% among the overall population; meanwhile, its incidence was gradually enhanced across the quartiles of TG/HDL-C ratio (0.61, 1.28, 2.55 and 4.25% respectively). Then the multivariate factors were adjusted. The multivariate cox regression analysis results showed that the hazard ratio of NAFLD in higher quartiles (Q2-Q4) was 2.10 (1.33-3.32), 3.11 (2.03-4.75) and 3.40 (2.24-5.17), respectively. Besides, the area under receiver operator characteristic curve (AUC) of TG/HDL-C ratio in the male was 0.70 (0.68-0.72) and 0.72 (0.70-0.75) in the female. The final values were dramatically larger than the other lipid index.
CONCLUSION
There is an independent relationship between TG/HDL-C and NAFLD among non-obese Chinese population without dyslipidemia, and TG/HDL-C may be used as a better predictor for NAFLD.
更新日期：2019-08-09
京公网安备 11010802027423号