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Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2019-10-22 , DOI: 10.1186/s12944-019-1116-2
Ting-Ting Wu , Ying-Ying Zheng , You Chen , Zi-Xiang Yu , Yi-Tong Ma , Xiang Xie

The relation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains controversial. The present study aims to assess the prognostic value of MHR in patients with CAD who underwent PCI. A total of 673 CAD patients were retrospectively enrolled and divided into four groups according to MHR values. Multivariate Cox regression analysis was performed to study the effects of different variables to clinical outcomes reported as major adverse cardiac events (MACE) and all-cause mortality (ACM). In a multivariate Cox analysis, after adjustment of other confounders, MHR was found to be an independent predictor of ACM (HR: 3.655; 95% CI: 1.170–11.419, P = 0.026) and MACE (HR =2.390, 95% CI 1.379–4.143, p < 0.002). Having a MHR in the third and fourth quartile were associated with a 2.83-fold and 3.26 -flod increased risk of MACE. MHR is an independent predictor of ACM and MACE in CAD patients undergoing PCI.

中文翻译:

单核细胞与高密度脂蛋白胆固醇比作为经皮冠状动脉介入治疗冠心病患者的长期预后指标

单核细胞与高密度脂蛋白胆固醇比率(MHR)和接受经皮冠状动脉介入治疗(PCI)的冠状动脉疾病(CAD)之间的关系仍然存在争议。本研究旨在评估MHR在接受PCI的CAD患者中的预后价值。回顾性纳入673名CAD患者,并根据MHR值将其分为四组。进行多变量Cox回归分析以研究不同变量对报告为主要不良心脏事件(MACE)和全因死亡率(ACM)的临床结果的影响。在多因素Cox分析中,在调整了其他混杂因素之后,发现MHR是ACM(HR:3.655; 95%CI:1.170-11.419,P = 0.026)和MACE(HR = 2.390,95%CI 1.379)的独立预测因子。 –4.143,p <0.002)。在第三个和第四个四分位数中拥有MHR会导致MACE风险增加2.83倍和3.26-flod。MHR是接受PCI的CAD患者ACM和MACE的独立预测因子。
更新日期:2019-10-22
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