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In-vivo validation of interpolation-based phase offset correction in cardiovascular magnetic resonance flow quantification: a multi-vendor, multi-center study.
Journal of Cardiovascular Magnetic Resonance ( IF 6.4 ) Pub Date : 2019-05-20 , DOI: 10.1186/s12968-019-0538-3
Mark B M Hofman 1 , Manouk J A Rodenburg 1 , Karin Markenroth Bloch 2, 3 , Beat Werner 4 , Jos J M Westenberg 5 , Emanuela R Valsangiacomo Buechel 6 , Robin Nijveldt 7 , Onno A Spruijt 8 , Philip J Kilner 9 , Albert C van Rossum 7 , Peter D Gatehouse 9
Affiliation  

BACKGROUND A velocity offset error in phase contrast cardiovascular magnetic resonance (CMR) imaging is a known problem in clinical assessment of flow volumes in vessels around the heart. Earlier studies have shown that this offset error is clinically relevant over different systems, and cannot be removed by protocol optimization. Correction methods using phantom measurements are time consuming, and assume reproducibility of the offsets which is not the case for all systems. An alternative previously published solution is to correct the in-vivo data in post-processing, interpolating the velocity offset from stationary tissue within the field-of-view. This study aims to validate this interpolation-based offset correction in-vivo in a multi-vendor, multi-center setup. METHODS Data from six 1.5 T CMR systems were evaluated, with two systems from each of the three main vendors. At each system aortic and main pulmonary artery 2D flow studies were acquired during routine clinical or research examinations, with an additional phantom measurement using identical acquisition parameters. To verify the phantom acquisition, a region-of-interest (ROI) at stationary tissue in the thorax wall was placed and compared between in-vivo and phantom measurements. Interpolation-based offset correction was performed on the in-vivo data, after manually excluding regions of spatial wraparound. Correction performance of different spatial orders of interpolation planes was evaluated. RESULTS A total of 126 flow measurements in 82 subjects were included. At the thorax wall the agreement between in-vivo and phantom was - 0.2 ± 0.6 cm/s. Twenty-eight studies were excluded because of a difference at the thorax wall exceeding 0.6 cm/s from the phantom scan, leaving 98. Before correction, the offset at the vessel as assessed in the phantom was - 0.4 ± 1.5 cm/s, which resulted in a - 5 ± 16% error in cardiac output. The optimal order of the interpolation correction plane was 1st order, except for one system at which a 2nd order plane was required. Application of the interpolation-based correction revealed a remaining offset velocity of 0.1 ± 0.5 cm/s and 0 ± 5% error in cardiac output. CONCLUSIONS This study shows that interpolation-based offset correction reduces the offset with comparable efficacy as phantom measurement phase offset correction, without the time penalty imposed by phantom scans. TRIAL REGISTRATION The study was registered in The Netherlands National Trial Register (NTR) under TC 4865 . Registered 19 September 2014. Retrospectively registered.

中文翻译:

心血管磁共振血流定量中基于插值的相位偏移校正的体内验证:多供应商,多中心研究。

背景技术相衬心血管磁共振(CMR)成像中的速度偏移误差是在临床上评估心脏周围血管中的血流量的已知问题。较早的研究表明,此偏移误差在不同系统上具有临床相关性,不能通过协议优化消除。使用幻像测量的校正方法非常耗时,并且假定偏移的可重复性,而并非所有系统都如此。先前发布的替代解决方案是在后处理中校正体内数据,对视野内静止组织的速度偏移进行插值。这项研究旨在在多供应商,多中心设置中验证这种基于插值的体内偏移校正。方法对来自六个1.5 T CMR系统的数据进行了评估,三个主要供应商各自提供两个系统。在每个系统中,在常规临床或研究检查期间进行了主动脉和主肺动脉的二维血流研究,并使用相同的采集参数进行了额外的幻像测量。为了验证幻影采集,在胸壁的固定组织处放置了一个感兴趣区域(ROI),并在体内和幻影测量之间进行了比较。在手动排除空间环绕区域之后,对体内数据执行基于插值的偏移校正。评估了插值平面不同空间顺序的校正性能。结果包括82位受试者的126次流量测量。在胸壁处,体内和体模之间的一致性为-0.2±0.6 cm / s。28项研究被排除在外是因为与幻影扫描相比,胸腔壁处的差异超过0.6 cm / s,留下了98个。校正之前,在幻影中评估的血管偏移为-0.4±1.5 cm / s,导致-5±16%的心输出量误差。插补校正平面的最佳顺序是一阶,除了一个需要二阶平面的系统。基于插值的校正的应用显示出剩余的偏移速度为0.1±0.5 cm / s,并且心输出量的误差为0±5%。结论这项研究表明,基于插值的偏移校正可以减少偏移,具有与幻像测量相位偏移校正相当的功效,而不会因幻像扫描而造成时间损失。试验注册本研究已在TC 4865下在荷兰国家试验注册局(NTR)中进行了注册。2014年9月19日注册。追溯注册。
更新日期:2019-05-20
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