OBJECTIVES We sought to: (1) determine the agreement in cardiovascular magnetic resonance (CMR) and speckle tracking echocardiography (STE) derived strain measurements, (2) compare their reproducibility, (3) determine which approach is best related to CMR late gadolinium enhancement (LGE). BACKGROUND While STE-derived strain is routinely used to assess left ventricular (LV) function, CMR strain measurements are not yet standardized. Strain can be measured using dedicated pulse sequences (strain-encoding, SENC), or post-processing of cine images (feature tracking, FT). It is unclear whether these measurements are interchangeable, and whether strain can be used as an alternative to LGE. METHODS Fifty patients underwent 2D echocardiography and 1.5 T CMR. Global longitudinal strain (GLS) was measured by STE (Epsilon), FT (NeoSoft) and SENC (Myocardial Solutions) and circumferential strain (GCS) by FT and SENC. RESULTS GLS showed good inter-modality agreement (r-values: 0.71-0.75), small biases (< 1%) but considerable limits of agreement (- 7 to 8%). The agreement between the CMR techniques was better for GLS than GCS (r = 0.81 vs 0.67; smaller bias). Repeated measurements showed low intra- and inter-observer variability for both GLS and GCS (intraclass correlations 0.86-0.99; coefficients of variation 3-13%). LGE was present in 22 (44%) of patients. Both SENC- and FT-derived GLS and GCS were associated with LGE, while STE-GLS was not. Irrespective of CMR technique, this association was stronger for GCS (AUC 0.77-0.78) than GLS (AUC 0.67-0.72) and STE-GLS (AUC = 0.58). CONCLUSION There is good inter-technique agreement in strain measurements, which were highly reproducible, irrespective of modality or analysis technique. GCS may better reflect the presence of underlying LGE than GLS.

中文翻译：

---

超声心动图和心血管磁共振评估心肌应变以及与晚期and增强的关系。

目的我们试图：（1）确定在心血管磁共振（CMR）和斑点跟踪超声心动图（STE）衍生的应变测量结果中的一致性，（2）比较它们的可重复性，（3）确定哪种方法与CMR晚期late增强最相关（LGE）。背景技术尽管通常将STE衍生应变用于评估左心室（LV）功能，但CMR应变测量尚未标准化。可以使用专用脉冲序列（应变编码，SENC）或电影图像的后处理（特征跟踪，FT）来测量应变。尚不清楚这些测量值是否可以互换，以及应变是否可以用作LGE的替代方法。方法50例患者接受了2D超声心动图和1.5 T CMR检查。整体纵向应变（GLS）由STE（Epsilon）测量，FT和SENC提供了FT（NeoSoft）和SENC（心肌解决方案）和圆周应变（GCS）。结果GLS显示良好的多模态一致性（r值：0.71-0.75），较小的偏倚（<1％）但一致性的极限（-7至8％）。对于GLS，CMR技术之间的一致性比GCS更好（r = 0.81 vs 0.67；偏差更小）。重复的测量显示，GLS和GCS的观察者内和观察者间变异性都低（类内相关系数0.86-0.99；变异系数3-13％）。LGE存在于22名患者中（44％）。SENC和FT衍生的GLS和GCS均与LGE相关，而STE-GLS不相关。无论使用CMR技术如何，GCS（AUC 0.77-0.78）的关联都比GLS（AUC 0.67-0.72）和STE-GLS（AUC = 0.58）强。结论应变测量方面有很好的技术间协议，无论采用何种形式或分析技术，都具有很高的可重复性。与GLS相比，GCS可能更好地反映了基础LGE的存在。