BACKGROUND Dengue is a global disease, transmitted by the Aedes vectors. In 2018, there were 80 615 dengue cases with 147 deaths in Malaysia. Currently, the nationwide surveillance programs are dependent on Aedes larval surveys and notifications of lab-confirmed human infections. The existing, reactive programs appear to lack sensitivity and proactivity. More efficient dengue vector surveillance/control methods are needed. METHODS A parallel, cluster, randomized controlled, interventional trial is being conducted for 18 months in Damansara Damai, Selangor, Malaysia, to determine the efficacy of using gravid oviposition sticky (GOS) trap and dengue non-structural 1 (NS1) antigen test for early surveillance of dengue among Aedes mosquitoes to reduce dengue outbreaks. Eight residential apartments were randomly assigned into intervention and control arms. GOS traps are set at the apartments to collect Aedes weekly, following which dengue NS1 antigen is detected in these mosquitoes. When a dengue-positive mosquito is detected, the community will be advised to execute vector search-and-destroy and protective measures. The primary outcome concerns the the percentage change in the (i) number of dengue cases and (ii) durations of dengue outbreaks. Whereas other outcome measures include the change in density threshold of Aedes and changes in dengue-related knowledge, attitude and practice among cluster inhabitants. DISCUSSION This is a proactive and early dengue surveillance in the mosquito vector that does not rely on notification of dengue cases. Surveillance using the GOS traps should be able to efficiently provide sufficient coverage for multistorey dwellings where population per unit area is likely to be higher. Furthermore, trapping dengue-infected mosquitoes using the GOS trap, helps to halt the dengue transmission carried by the mosquito. It is envisaged that the results of this randomized controlled trial will provide a new proactive, cheap and targeted surveillance tool for the prevention and control of dengue outbreaks. TRIAL REGISTRATION This is a parallel-cluster, randomized controlled, interventional trial, registered at ClinicalTrials.gov (ID: NCT03799237), on 8th January 2019 (retrospectively registered).

中文翻译：

---

用于多层住宅中登革热早期监测的妊娠卵胎生黏性陷阱和登革热非结构性1抗原测试：一项集群随机对照试验的研究方案。

背景技术登革热是一种全球性疾病，由伊蚊传播。2018年，马来西亚有80615例登革热病例，其中147人死亡。目前，全国范围的监视计划依赖于伊蚊幼虫调查和实验室确认的人类感染的通知。现有的反应式程序似乎缺乏敏感性和主动性。需要更有效的登革热媒介监视/控制方法。方法在马来西亚雪兰莪州的Damansara Damai进行了一项平行，随机，随机对照的干预性试验，为期18个月，以确定使用妊娠产卵黏附（GOS）诱集剂和登革热非结构性1（NS1）抗原检测的有效性。尽早监测伊蚊的登革热，以减少登革热的暴发。八个住宅公寓被随机分配到干预和控制部门。在公寓设置了GOS捕集阱，每周收集一次伊蚊，然后在这些蚊子中检测到登革热NS1抗原。当发现登革热阳性蚊子时，将建议社区采取媒介搜寻和破坏措施以及保护措施。主要结果涉及（i）登革热病例数和（ii）登革热暴发持续时间的百分比变化。而其他结果指标包括伊蚊密度阈值的变化以及人群中登革热相关知识，态度和行为的变化。讨论这是对蚊媒的一种积极主动的早期登革热监视，它不依赖于登革热病例的通报。使用GOS陷阱进行监视应该能够有效地为多层住宅提供足够的覆盖，在多层住宅中，单位面积的人口可能会更高。此外，使用GOS诱捕器诱捕登革热感染的蚊子有助于阻止蚊子携带的登革热传播。可以预期，这项随机对照试验的结果将为预防和控制登革热暴发提供一种新的，主动的，廉价的和有针对性的监测工具。试验注册这是一项平行研究，随机对照，干预性试验，于2019年1月8日在ClinicalTrials.gov（ID：NCT03799237）进行了注册（回顾性注册）。有助于阻止蚊子传播的登革热。可以预期，这项随机对照试验的结果将为预防和控制登革热暴发提供一种新的，主动的，廉价的和有针对性的监测工具。试验注册这是一项平行研究，随机对照，干预性试验，于2019年1月8日在ClinicalTrials.gov（ID：NCT03799237）进行了注册（回顾性注册）。有助于阻止蚊子传播的登革热。可以预期，这项随机对照试验的结果将为预防和控制登革热暴发提供一种新的，主动的，廉价的和有针对性的监测工具。试验注册这是一项平行研究，随机对照，干预性试验，于2019年1月8日在ClinicalTrials.gov（ID：NCT03799237）进行了注册（回顾性注册）。