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High helminthic co-infection in tuberculosis patients with undernutritional status in northeastern Ethiopia
Infectious Diseases of Poverty ( IF 8.1 ) Pub Date : 2019-10-18 , DOI: 10.1186/s40249-019-0600-2
Fikru Gashaw , Samuel Bekele , Yalemtsehay Mekonnen , Girmay Medhin , Gobena Ameni , Berhanu Erko

Tuberculosis and parasitosis are the widely distributed diseases in Ethiopia with the leading cause of mortality and morbidity, respectively. There has been no information on the status of co-infections of tuberculosis and parasitosis in Oromia Zone of Amhara Region and South Wollo, Ethiopia. Hence, this study primarily focuses on determining the status of tuberculosis and parasitosis co-infections and associated factors. The study was conducted in Oromia Special Zone of the Amhara Regional State and South Wollo Zone, northeastern Ethiopia from April 2015 to January 2017. Tuberculosis cases confirmed by health personnel at the health institutions were the source of the study sample. In a cross-sectional study 384 smear positive pulmonary and extra-pulmonary tuberculosis cases were recruited. Faecal specimens provided by the study participants were examined for parasitic co-infections using direct saline microscopic test, Kato-Katz and concentration techniques. Nutritional status was determined using body mass index and mid-upper arm circumferences. Data were analyzed using descriptive statistical methods and Pearson chi-square. Tuberculosis and parasitosis co-infection prevalence was 10.8%, and the proportion of intestinal helminths accounted for 9.7% while intestinal protozoa accounted for 1.9%. Cases with single parasitic infection was 89.3% among co-infected individuals. Co-infection of both disease was not significantly associated with gender and age (P > 0.05). The prevalence of undernutrition was 58.6% as determined using body mass index and 73.0% as determined using mid-upper arm circumference with no significant association with gender. Among all forms of tuberculosis cases (384) screened for the study, the bacterial positivity was relatively more common in males (55.5%) than females (44.5%). Tuberculosis lymphadenitis was found to be the most prevalent (85.9%) form of extra-pulmonary tuberculosis with cervical adenopathy (75.3%) being the commonly existing disease. The rate of helminthic co-infection is predominantly high than that of intestinal protozoa. Single parasitic co-infection was more common than double or multiple co-infections. Both body mass index and mid-upper arm circumference anthropometric parameters revealed greater risk of undernutrition in tuberculosis patients. Thus, screening and prompt treatment of parasites in tuberculosis patients and a support of nutritional supplementation for malnourished tuberculosis patients should be further studied which might enhance the disease treatment and minimize the risk of its complexity.

中文翻译:

埃塞俄比亚东北部营养不良的结核病患者发生高蠕虫病合并感染

结核和寄生虫病是埃塞俄比亚分布广泛的疾病,分别是导致死亡和发病的主要原因。在阿姆哈拉地区的奥罗米亚地区和埃塞俄比亚的南沃尔洛,尚无关于结核病和寄生虫病合并感染状况的信息。因此,本研究主要侧重于确定结核和寄生虫合并感染的状况以及相关因素。该研究于2015年4月至2017年1月在埃塞俄比亚东北部阿姆哈拉州州的奥罗米亚特区和南沃尔洛地区进行。研究样本由卫生机构的卫生人员确认为结核病病例。在一项横断面研究中,招募了384例涂片阳性的肺结核和肺外结核病例。使用直接生理盐水镜检,Kato-Katz和浓缩技术对研究参与者提供的粪便标本进行寄生共感染检查。营养状况是通过体重指数和上臂中围确定的。使用描述性统计方法和Pearson卡方检验分析数据。结核和寄生虫病的合并感染率为10.8%,肠道蠕虫的比例为9.7%,而原生动物的比例为1.9%。在合并感染的个体中,单一寄生虫感染的病例为89.3%。两种疾病的共同感染与性别和年龄均无显着相关性(P> 0.05)。根据体重指数和73,营养不良发生率为58.6%。使用上臂中上围测定的值为0%,与性别无明显关联。在为研究筛选的所有形式的结核病例中(384),男性(55.5%)的细菌阳性率相对于女性(44.5%)更为常见。已发现结核性淋巴结炎是肺外结核的最普遍形式(85.9%),而宫颈腺病(75.3%)是普遍存在的疾病。蠕虫感染的比率主要高于肠道原生动物。单一寄生虫合并感染比双重或多重合并感染更为常见。体重指数和上臂中段人体测量参数均显示结核病患者营养不良的风险更大。因此,
更新日期:2019-10-18
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