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Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015–2016 Malawi micronutrient survey
Infectious Diseases of Poverty ( IF 8.1 ) Pub Date : 2019-11-25 , DOI: 10.1186/s40249-019-0607-8
Peter Austin Morton Ntenda , Sosten Chilumpha , Edward Tisungane Mwenyenkulu , Jane Flora Kazambwe , Walaa El-Meidany

Anaemia and malaria are common and life-threatening diseases among preschool-aged children in many tropical and subtropical areas, and Malawi is no exception. Accordingly, this study aimed to examine the association of referral clinical malaria with anemia (hemoglobin [Hb] < 110 g/L) in preschool-aged children in Malawi. Using cross-sectional data obtained from the 2015–2016 Malawi Micronutrient Survey (MNS), multivariate logistic regression models were constructed using surveylogistic to account for the complex survey design. Blood samples of 1051 children aged 6–59 months were evaluated for malaria (using rapid diagnostic test [RDT] – SD BIOLINE Malaria Ag P.f/Pan test histidine-rich protein (HRP-II)™), Hb (using HemoCue 301), α-1-acid glycoprotein (AGP), and serum ferritin biomarkers (using simple sandwich enzyme-linked immunosorbent assay technique, ELISA) and inherited blood disorders from dry blood samples (DBS) using polymerize chain reaction (PCR). Diagnosis of clinical malaria was made on the basis of fever and a positive rapid diagnostic test (RDT). Of the 1051 PSC analysed, 29% had anaemia while 24.4% had a referral to the hospital due to malaria. After adjustments for known confounders, PSC with a history of referral clinical malaria had increased odds of being anaemic (adjusted odds ratio [aOR] = 4.63, 95% confidence interval [CI]: 2.90–7.40), P <  0.0001. This study found that clinical malaria increased the risk of anaemia in PSC. Thus, elimination of malaria-causing parasites from the PSC’s blood should be rapid and complete in order to prevent the progression of uncomplicated malaria to a chronic infection that can lead to the development of malaria-related anaemia.

中文翻译:

学龄前儿童中的临床疟疾和贫血的潜在风险:一项基于人群的2015-2016年马拉维微量营养素调查研究

在许多热带和亚热带地区,贫血和疟疾是学龄前儿童中常见的威胁生命的疾病,马拉维也不例外。因此,本研究旨在检查马拉维学龄前儿童转诊临床疟疾与贫血(血红蛋白[Hb] <110 g / L)之间的关系。使用从2015-2016年马拉维微量营养素调查(MNS)获得的横截面数据,使用Surveylogistic构建多元Logistic回归模型,以说明复杂的调查设计。对1051名6至59个月大的儿童的血液样本进行了疟疾评估(使用快速诊断测试[RDT] – SD BIOLINE疟疾Ag Pf / Pan测试富含组氨酸的蛋白(HRP-II)™),血红蛋白(使用HemoCue 301), α-1-酸糖蛋白(AGP),和血清铁蛋白生物标志物(使用简单的夹心酶联免疫吸附测定技术,ELISA),以及通过聚合链反应(PCR)从干血样品(DBS)中遗传的血液疾病。根据发烧和阳性快速诊断测试(RDT)对临床疟疾进行诊断。在分析的1051个PSC中,有29%患有贫血,而24.4%因疟疾转诊至医院。在对已知混杂因素进行调整后,具有转诊临床疟疾史的PSC贫血几率增加(调整后的优势比[aOR] = 4.63,95%置信区间[CI]:2.90–7.40),P <0.0001。这项研究发现临床疟疾增加了PSC贫血的风险。因此,
更新日期:2019-11-25
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