Previous studies have reported that fine particle (PM2.5) concentrations triggered ST elevation myocardial infarctions (STEMI). In Rochester, NY, multiple air quality policies and economic changes/influences from 2008 to 2013 led to decreased concentrations of PM2.5 and its major constituents (SO42−, NO3−, elemental and primary organic carbon). This study examined whether the rate of STEMI associated with increased ambient gaseous and PM component concentrations was different AFTER these air quality policies and economic changes (2014–2016), compared to DURING (2008–2013) and BEFORE these polices and changes (2005–2007). Using 921 STEMIs treated at the University of Rochester Medical Center (2005–2016) and a case-crossover design, we examined whether the rate of STEMI associated with increased PM2.5, ultrafine particles (UFP, < 100 nm), accumulation mode particles (AMP, 100-500 nm), black carbon, SO2, CO, and O3 concentrations in the previous 1–72 h was modified by the time period related to these pollutant source changes (BEFORE, DURING, AFTER). Each interquartile range (3702 particles/cm3) increase in UFP concentration in the previous 1 h was associated with a 12% (95% CI = 3%, 22%) increase in the rate of STEMI. The effect size was larger in the AFTER period (26%) than the DURING (5%) or BEFORE periods (9%). There were similar patterns for black carbon and SO2. An increased rate of STEMI associated with UFP and other pollutant concentrations was higher in the AFTER period compared to the BEFORE and DURING periods. This may be due to changes in PM composition (e.g. higher secondary organic carbon and particle bound reactive oxygen species) following these air quality policies and economic changes.

中文翻译：

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随着时间的流逝，纽约门罗县的微粒空气污染引发ST抬高性心肌梗死的变化：病例交叉研究

先前的研究报道，细颗粒物（PM2.5）浓度可引发ST抬高型心肌梗塞（STEMI）。在纽约州罗切斯特，2008年至2013年的多项空气质量政策和经济变化/影响导致PM2.5及其主要成分（SO42-，NO3-，元素和主要有机碳）的浓度降低。这项研究调查了在这些空气质量政策和经济变化之后（2014-2016年），相比于持续时间（2008-2013年）以及这些政策和变化之前（2005-2016年），与周围气体和PM组分浓度增加相关的STEMI率是否有所不同。 2007）。我们使用罗切斯特大学医学中心（2005-2016）治疗的921例STEMI和病例交叉设计，检查了STEMI的发生率是否与PM2.5，超细颗粒（UFP，<100 nm）的增加，累积模式颗粒（AMP，100-500 nm），黑碳，SO2，CO和O3的浓度在之前的1–72小时内被与这些污染物源变化相关的时间段（之前，期间，之后）进行了修改。在前1小时内，UFP浓度每增加一个四分位数范围（3702个粒子/ cm3），则STEMI率增加12％（95％CI = 3％，22％）。在AFTER期间（26％）大于（DURING）期间（5％）或BEFORE之前（9％）的效果大小。炭黑和二氧化硫也有相似的模式。与之后和期间相比，在之后阶段，与UFP和其他污染物浓度相关的STEMI上升率更高。这可能是由于PM成分的变化（例如