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Association between prenatal exposure to perfluoroalkyl substances and asthma in 5-year-old children in the Odense Child Cohort
Environmental Health ( IF 6 ) Pub Date : 2019-11-15 , DOI: 10.1186/s12940-019-0541-z
Iben Have Beck , Clara Amalie Gade Timmermann , Flemming Nielsen , Greet Schoeters , Camilla Jøhnk , Henriette Boye Kyhl , Arne Høst , Tina Kold Jensen

Asthma is the most common non-communicable disease in children. Prenatal exposure to perfluoroalkyl substances (PFASs), a group of persistent environmental chemicals with endocrine disrupting abilities, has been associated with immunomodulation and may contribute to the aetiology of asthma. We investigated the associations between prenatal exposure to five PFASs and asthma in 5-year-old children. We studied 981 mother-child pairs within the Odense Child Cohort (OCC), Denmark. We measured perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) in maternal serum donated in early pregnancy. A standardized questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC) was used to assess wheeze, self-reported asthma and doctor-diagnosed asthma among children at age 5 years. Associations were examined using logistic regression analyses adjusting for parity, maternal educational level, maternal pre-pregnancy BMI, asthma predisposition and child sex. Among the 5-year-old children 18.6% reported wheeze and 7.1% reported asthma. We found no association between prenatal exposure to PFAS and doctor-diagnosed asthma or wheeze. Prenatal PFAS exposure was associated with self-reported asthma, although only significant for PFNA (OR = 1.84, 95% CI 1.03,3.23). Our findings support the suggested immunomodulatory effects of PFASs, however, additional studies are warranted. In order to verify our findings, it is important to re-examine the children with postnatal measurements of serum PFAS concentrations and additional clinical diagnostic testing at an older age where an asthma diagnosis is more valid.

中文翻译:

欧登塞儿童队列中5岁儿童的产前暴露于全氟烷基物质与哮喘之间的关联

哮喘是儿童中最常见的非传染性疾病。产前暴露于全氟烷基物质(PFAS)是一组具有内分泌干扰能力的持久性环境化学物质,与免疫调节有关,可能与哮喘的病因有关。我们调查了五岁儿童的产前五种全氟辛烷磺酸暴露与哮喘之间的关系。我们在丹麦的欧登塞儿童队列(OCC)中研究了981对母子。我们测量了妊娠早期捐赠的孕妇血清中的全氟辛烷磺酸(PFOS),全氟辛酸(PFOA),全氟己烷磺酸(PFHxS),全氟壬酸(PFNA)和全氟癸酸(PFDA)。根据《儿童哮喘和过敏国际研究》(ISAAC)编制的标准化问卷用于评估喘息,5岁儿童的自我报告的哮喘和医生诊断的哮喘。使用逻辑回归分析对协会进行了检查,校正了均等,母体教育水平,母体孕前BMI,哮喘易感性和儿童性别。在5岁儿童中,有18.6%的人报告有喘息,有7.1%的人报告有哮喘。我们发现产前暴露于PFAS与医生诊断的哮喘或喘息之间没有关联。产前PFAS暴露与自我报告的哮喘有关,尽管仅对PFNA有意义(OR = 1.84,95%CI 1.03,3.23)。我们的发现支持建议的PFAS的免疫调节作用,但是,还需要进行其他研究。为了验证我们的发现,
更新日期:2019-11-15
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