Phosphatidylserine (PtdSer), an essential constituent of eukaryotic membranes, is the most abundant anionic phospholipid in the eukaryotic cell accounting for up to 10% of the total cellular lipid. Much of what is known about PtdSer is the role exofacial PtdSer plays in apoptosis and blood clotting. However, PtdSer is generally not externally exposed in healthy cells and plays a vital role in several intracellular signaling pathways, though relatively little is known about the precise subcellular localization, transmembrane topology and intracellular dynamics of PtdSer within the cell. The recent development of new, genetically-encoded probes able to detect phosphatidylserine is leading to a more in-depth understanding of the biology of this phospholipid. This review aims to give an overview of recent developments in our understanding of the role of PtdSer in intracellular signaling events derived from the use of these recently developed methods of phosphatidylserine detection.

中文翻译：

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磷脂酰丝氨酸在细胞内的分布，动力学和功能作用。

磷脂酰丝氨酸（PtdSer）是真核细胞膜的重要组成部分，是真核细胞中最丰富的阴离子磷脂，占细胞脂质总量的10％。关于PtdSer的许多已知信息是面颊PtdSer在细胞凋亡和血液凝结中扮演的角色。然而，尽管对PtdSer的精确亚细胞定位，跨膜拓扑和细胞内PtdSer的动态知之甚少，但是PtdSer通常不会在健康细胞中对外暴露，并且在几种细胞内信号通路中起着至关重要的作用。能够检测磷脂酰丝氨酸的新的，经过基因编码的探针的最新开发正在导致对该磷脂生物学的更深入的了解。