Neuroendocrine (NE) cells may have an impact on the development and initial growth of benign prostatic hyperplasia (BPH) according to previous human studies. To explore the relationship of NE cells and BPH development, we compared the density of NE cells and also prostatic weight in spontaneously hypertensive rats (SHR), which develop by aging, and Wistar-Kyoto rats (WKY) as control. The total weights of the epithelium and stroma in the ventral lobes of 8-, 12, 16-, 28- and 56-week-old SHR and WKY were calculated using Image J software. NE cells in the ventral prostatic ducts (VPd) were quantified using immunohistochemical staining for serotonin. Although there was no significant difference in the estimated total weight of the epithelium and stroma in the ventral lobes adjusted by body weight (ES weight) between the two groups at 8, 12 and 16 weeks of age, ES weight was significantly greater in the SHR group than in the WKT group at 28 and 56 weeks. The density of NE cells in the VPd decreased with aging in the WKY group, whereas it was sustained until 16 weeks and then decreased with aging in the SHR group. The difference in the density between the two groups was most marked at 16 weeks of age. In the natural history of BPH, NE cells may play an important role in the initial development of BPH because sustained density of NE cells in the VPd precedes the development of prostatic hyperplasia.

中文翻译：

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自发性高血压大鼠中神经内分泌细胞的持续密度随年龄增长而先于前列腺增生

根据先前的人体研究，神经内分泌（NE）细胞可能对良性前列腺增生（BPH）的发育和初始生长产生影响。为了探讨NE细胞与BPH发育的关系，我们比较了衰老形成的自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）的NE细胞密度以及前列腺重量。使用Image J软件计算8、12、16、28和56周龄SHR和WKY腹侧叶上皮和基质的总重量。使用5-羟色胺的免疫组织化学染色定量腹侧前列腺导管（VPd）中的NE细胞。尽管两组的体重（ES体重）调整后，腹侧叶上皮和间质的估计总重量没有显着差异，但在8岁时，在12周和16周龄时，SHR组的ES体重在28周和56周时显着大于WKT组。在WKY组中，VPd中NE细胞的密度随着年龄的增长而降低，而在SHR组中，其维持到16周后一直下降。两组之间的密度差异在16周龄时最为明显。在BPH的自然史中，NE细胞可能在BPH的初始发育中起重要作用，因为VPd中NE细胞的持续密度先于前列腺增生的发生。两组之间的密度差异在16周龄时最为明显。在BPH的自然史中，NE细胞可能在BPH的初始发育中起重要作用，因为VPd中NE细胞的持续密度先于前列腺增生的发生。两组之间的密度差异在16周龄时最为明显。在BPH的自然史中，NE细胞可能在BPH的初始发育中起重要作用，因为VPd中NE细胞的持续密度先于前列腺增生的发生。