We investigated the surgical feasibility, safety and effectiveness of 50 W (low power) Holmium Laser enucleation of the prostate (HoLEP) in patients who have undergone previous template biopsy of the prostate (TPB). Data encompassing pre-operative baseline characteristics, intra-operative measures and post-operative outcomes was collected for 109 patients undergoing HoLEP across two UK centres. Patients were stratified into two groups; group 1 (n = 24) had undergone previous TPB were compared with ‘controls’ (no previous TPB) in group 2 (n = 85). The primary outcome was successful HoLEP. There were no statistically significant differences in either key baseline characteristics or mass of prostate enucleated between groups 1 and 2. There was no statistically significant difference in enucleation or morcellation times parameters between the two groups other than enucleation efficiency in favour of group 1 (p = 0.024). Functional outcomes improved, without any statistically significant difference, in both groups. In patients with a previous TPB, HoLEP is surgically feasible, safe and effective. TPB should not be considered a contraindication to HoLEP. Our work provides a strong foundation for further research in this area.

中文翻译：

---

经previous会阴活检（TPB）患者中of激光摘除术（HoLEP）的安全性和有效性：双中心病例对照研究的结果

我们调查了以前接受过前列腺模板活检（TPB）的患者使用50 W（低功率）Hol激光前列腺摘除术（HoLEP）的手术可行性，安全性和有效性。在英国的两个中心收集了109例接受HoLEP治疗的患者的数据，这些数据包括术前基线特征，术中措施和术后结局。患者分为两组。将第1组（n = 24）接受过先前的TPB与第2组（n = 85）的“对照”（无先前的TPB）进行比较。主要结果是成功的HoLEP。第1组和第2组之间的主要基线特征或摘除前列腺的质量在统计学上无显着差异。除对第1组有利的摘除效率外，两组的摘除或粉碎时间参数在统计学上无显着差异（p = 0.024）。两组的功能结局均得到改善，但无统计学意义上的显着差异。对于先前患有TPB的患者，HoLEP手术可行，安全且有效。TPB不应被视为HoLEP的禁忌症。我们的工作为该领域的进一步研究奠定了坚实的基础。