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CoQ10 ameliorates monosodium glutamate-induced alteration in detrusor activity and responsiveness in rats via anti-inflammatory, anti-oxidant and channel inhibiting mechanisms
BMC Urology ( IF 2 ) Pub Date : 2019-10-28 , DOI: 10.1186/s12894-019-0534-9
Dalia F. El Agamy , Yahya M. Naguib

Competent detrusor muscles with coordinated contraction and relaxation are crucial for normal urinary bladder storage and emptying functions. Hence, detrusor instability, and subsequently bladder overactivity, may lead to undesirable outcomes including incontinence. Multiple mechanisms may underlie the pathogenesis of detrusor overactivity including inflammation and oxidative stress. Herein, we tested the possibility that CoQ10 may have a potential therapeutic role in detrusor overactivity. Forty adult male Wistar albino rats weighing 100-150 g were used in the present study. Rats were divided (10/group) into control (receiving vehicles), monosodium glutamate (MSG)-treated (receiving 5 mg/kg MSG daily for 15 consecutive days), MSG + OO-treated (receiving concomitantly 5 mg/kg MSG and olive oil for 15 consecutive days), MSG + CoQ10-treated (receiving concomitantly 5 mg/kg MSG and 100 mg/kg CoQ10 daily for 15 consecutive days) groups. MSG resulted in significant increase in bladder weight and sensitised the bladder smooth muscles to acetylcholine. MSG has also resulted in significant increase in bladder TNF-α, IL-6, malondialdehyde, nerve growth factor and connexion 43, with significant decrease in the antioxidant enzymes superoxide dismutase and catalase. Olive oil had no effect on MSG induced alterations of different parameters. Treatment with CoQ10 has resulted in a significant restoration of all the altered parameters. Taken together, our results suggest that CoQ10 antagonizes the deleterious effects of MSG on detrusor activity. We propose that CoQ10 could be a therapeutic strategy targeting urinary bladder dysfunction.

中文翻译:

辅酶Q10通过抗炎,抗氧化剂和通道抑制机制改善了味精对大鼠逼尿肌活性和反应性的影响

逼尿肌具有协调的收缩和松弛能力,对于正常的膀胱存储和排空功能至关重要。因此,逼尿肌不稳定以及随后的膀胱过度活动可能导致不期望的结果,包括尿失禁。逼尿肌过度活跃的发病机理可能包括多种机制,包括炎症和氧化应激。在本文中,我们测试了辅酶Q10在逼尿肌过度活动中可能具有潜在治疗作用的可能性。在本研究中使用了40只体重100-150 g的成年雄性Wistar白化病大鼠。将大鼠分成10只/组,分为对照组(接受载体),味精(MSG)处理(连续15天每天接受5mg / kg味精),味精+ OO处理(同时接受5mg / kg味精和10mg / kg味精)。橄榄油连续15天),MSG + CoQ10治疗组(连续15天每天接受5 mg / kg MSG和100 mg / kg CoQ10)。MSG导致膀胱重量显着增加,并使膀胱平滑肌对乙酰胆碱敏感。MSG还导致膀胱TNF-α,IL-6,丙二醛,神经生长因子和连接43显着增加,而抗氧化酶超氧化物歧化酶和过氧化氢酶显着降低。橄榄油对味精诱导的不同参数改变没有影响。辅酶Q10的治疗已导致所有改变参数的显着恢复。两者合计,我们的结果表明辅酶Q10拮抗味精对逼尿肌活动的有害影响。我们建议辅酶Q10可能是针对膀胱功能障碍的治疗策略。
更新日期:2019-10-28
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