Background The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to compare the levels of arterial CVD risk markers between OA phenotypes and controls. Method The "Musculoskeletal pain in Ullensaker" Study (MUST) invited residents of Ullensaker municipality with self-reported OA to a medical examination. OA was defined according to the American College of Rheumatology (ACR) criteria and phenotyped based on joint distribution. Joints of the hands, hips and knees were examined by ultrasonography and conventional radiography, and scored for osteosteophytes. Hands were also scored for inflammation by grey scale (GS) synovitis and power Doppler (PD) signal. Control populations were a cohort of inhabitants of Oslo (OCP), and for external validation, a UK community-based register (UKPC).Pulse pressure augmentation index (AIx) and pulse wave velocity (PWV) were measured using the Sphygmocor apparatus (Atcor®). Ankel-brachial index (ABI) was estimated in a subset of patients. In separate adjusted regression models we explored the associations between ultrasonography and radiograph joint scores and AIx, PWV and ABI. CVD risk markers were also compared between phenotypes of OA and controls in adjusted analyses. Results Three hundred and sixty six persons with OA were included (mean age (range); 63.0 (42.0-75.0)), (females (%); 264 (72)). Of these, 155 (42.3%) had isolated hand OA, 111 (30.3%) had isolated lower limb OA and 100 (27.3%) had generalized OA. 108 persons were included in the OCP and 963 persons in the UKPC; (mean age (range); OCP: 57.2 (40.4-70.4), UKPC: 63.9 (40.0-75.0), females (%); OCP: 47 (43.5), UKPC: 543 (56.4%). Hand osteophytes were associated with AIx while GS and PD scores were not related to CVD risk markers. All OA phenotypes had higher levels of AIx compared to OCP in adjusted analyses. External validation against UKPC confirmed these findings. Conclusions Hand osteophytes might be related to higher risk of CVD. People with OA had higher augmented central pressure compared to controls.Words 330.

中文翻译：

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跨骨关节炎表型的心血管风险生物标志物。

背景 本研究的目的是探讨骨关节炎 (OA) 患者的超声和影像学关节评分与动脉 CVD 风险标志物水平之间的关联。其次，比较 OA 表型和对照组之间动脉 CVD 风险标志物的水平。方法 “Ullensaker 的肌肉骨骼疼痛”研究 (MUST) 邀请 Ullensaker 市的自我报告 OA 的居民进行体检。OA 根据美国风湿病学会 (ACR) 标准定义，并根据联合分布进行表型分析。手、髋和膝关节通过超声检查和常规放射线照相术进行检查，并对骨赘进行评分。还通过灰度 (GS) 滑膜炎和能量多普勒 (PD) 信号对手的炎症进行评分。对照人群是一组奥斯陆居民 (OCP)，为了进行外部验证，使用英国社区登记册 (UKPC)。使用 Sphygmocor 仪器 (Atcor) 测量脉压增强指数 (AIx) 和脉搏波速度 (PWV) ®)。在一部分患者中估计了踝臂指数 (ABI)。在单独的调整回归模型中，我们探讨了超声检查和 X 光片联合评分与 AIx、PWV 和 ABI 之间的关联。在调整后的分析中，还比较了 OA 表型和对照之间的 CVD 风险标志物。结果共纳入 366 名 OA 患者（平均年龄（范围）；63.0（42.0-75.0）），（女性（%）；264（72））。其中，155 人（42.3%）患有孤立性手部 OA，111 人（30.3%）患有孤立性下肢 OA，100 人（27.3%）患有全身性 OA。OCP 108 人，UKPC 963 人；（平均年龄（范围）；OCP：57.2 (40.4-70.4)，UKPC：63.9 (40.0-75.0)，女性 (%)；OCP：47 (43.5)，UKPC：543 (56.4%)。手部骨赘与AIx 而 GS 和 PD 评分与 CVD 风险标志物无关。在调整后的分析中，所有 OA 表型的 AIx 水平都高于 OCP。针对 UKPC 的外部验证证实了这些发现。结论 手部骨赘可能与 CVD 风险升高有关。与对照组相比，患有 OA 的患者具有更高的增强中心压力。字 330。在调整后的分析中，与 OCP 相比，所有 OA 表型的 AIx 水平更高。针对 UKPC 的外部验证证实了这些发现。结论 手部骨赘可能与心血管疾病的高风险有关。与对照组相比，患有 OA 的人具有更高的增强中心压力。字 330。在调整后的分析中，与 OCP 相比，所有 OA 表型的 AIx 水平更高。针对 UKPC 的外部验证证实了这些发现。结论 手部骨赘可能与心血管疾病的高风险有关。与对照组相比，患有 OA 的人具有更高的增强中心压力。字 330。