BACKGROUND Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to have extensive potentials as an alternative for current antibiotics. Due to the huge costs for the study and the production of a new drug, if an antimicrobial peptide has other beneficial functions in addition to antimicrobial activities, it would be preferred. METHODS In this study, properties and applications of Epinecidin-1 were investigated and addressed comprehensively. To achieve this, the Google Scholar search engine and three databases of PubMed, Scopus, and Web of Science were used. RESULTS Epinecidin-1 is a cationic AMP with an alpha-helical structure. Seven functional usages of this peptide have been reported in the literature including antibacterial, antifungal, antiviral, antiprotozoal, anticancer, immunomodulatory, and wound healing properties. Moreover, this peptide has high potential to be used as an active ingredient in cleaning solutions as well as application in vaccine production. CONCLUSION Due to significant antimicrobial activities tested on bacteria such as Staphylococcus aureus and Helicobacter pylori and also wound healing properties, Epi-1 has high potential to be considered as an important candidate for the production of new drugs and treatment of various infections including diabetic foot ulcer and peptic ulcer. Moreover, adjuvant-like properties of Epi-1 make it a suitable candidate for the studies related to an adjuvant. Other attractive properties such as anticancer effects have also been reported for this peptide which encourages further studies on this peptide.

中文翻译：

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Epinecidin-1，一种高效的海洋抗菌肽，具有抗癌和免疫调节活性。

背景技术在本世纪中，抗生素抗性病原体是新兴的威胁。Epinecidin-1是一种由橙斑石斑鱼（Epinephelus coioides）生产的多功能抗菌肽（AMP），具有替代当前抗生素的广泛潜力。由于研究和生产新药的巨大成本，如果抗微生物肽除具有抗微生物活性外还具有其他有益功能，则将是首选。方法在本研究中，对Epinecidin-1的性质和应用进行了研究和全面研究。为此，使用了Google Scholar搜索引擎以及PubMed，Scopus和Web of Science的三个数据库。结果Epinecidin-1是具有α-螺旋结构的阳离子AMP。在文献中已经报道了该肽的七种功能用途，包括抗菌，抗真菌，抗病毒，抗原生动物，抗癌，免疫调节和伤口愈合特性。此外，该肽具有很高的潜力，可用作清洁溶液中的活性成分以及在疫苗生产中的应用。结论由于对金黄色葡萄球菌和幽门螺杆菌等细菌具有显着的抗菌活性以及伤口愈合特性，Epi-1具有很高的潜力，可被视为生产新药和治疗包括糖尿病足溃疡在内的各种感染的重要候选药物和消化性溃疡。此外，Epi-1的佐剂样特性使其成为与佐剂有关的研究的合适候选者。