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A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity
BMC Pharmacology and Toxicology ( IF 2.605 ) Pub Date : 2019-11-05 , DOI: 10.1186/s40360-019-0366-y
Xiaonian Han , Jinping Wang

The adverse drug reactions (ADRs) related to clonazepam are mild, and only two cases of myotoxicity induced by clonazepam have been reported, with both patients recovering well. We present a unique case of a serious ADR outcome after taking clonazepam. A 24-year-old woman with a long-standing history of polio and a 2-year history of epilepsy developed a serious ADR after repeated exposure to oral clonazepam combined with sodium valproate that manifested as myotoxicity and elevated levels of creatine phosphokinase. The patient is currently bedridden and unable to take care of herself. Clinicians should be vigilant of the possibility of myotoxicity induced by clonazepam, especially in specific populations such as polio patients or when clonazepam is used in combination therapies.

中文翻译:

氯硝西am可能引起的严重药物不良反应:1例肌毒性报告

与氯硝西am相关的药物不良反应(ADR)轻微,仅报道了2例由氯硝西am引起的肌毒性病例,两名患者均康复良好。我们介绍了服用氯硝西present后严重ADR严重后果的独特案例。一名患有小儿麻痹症历史悠久且患有癫痫病2年史的24岁妇女在反复接触口服氯硝西am和丙戊酸钠后出现严重的ADR,这表现为肌毒性和肌酸磷酸激酶水平升高。该患者目前卧床不起,无法照顾自己。临床医生应警惕氯硝西am引起的肌毒性的可能性,尤其是在小儿麻痹症患者等特定人群中或氯硝西am联合治疗时。
更新日期:2019-11-05
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