BACKGROUND The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status. METHODS The study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent assay. RESULTS The values of FOLR1 in GCF were higher in gingivitis and periodontitis groups than among patient in control group (p < 0.016). Serum FOLR1 levels showed no significant difference between the groups. A significant correlation was observed between FOLR1 levels of GCF and BOP (p < 0.05). CONCLUSIONS Our preliminary data suggest that FOLR1 is not useful in monitoring the periodontal disease. Further studies are necessary to clarify the role, regulation and function of folate and it's receptors in the pathogenesis of periodontal disease.

中文翻译：

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牙周病中的叶酸受体1水平：一项初步研究。

背景技术这项研究的目的是研究牙周状态不同的受试者的龈沟液（GCF）和血清叶酸受体1（FOLR1）的水平。方法该研究分为三组：健康组（n = 15），牙龈炎组（n = 15）和慢性牙周炎组（n = 15）。评估了临床牙周参数，包括探查袋深度（PPD），临床附着水平（CAL），牙龈指数（GI）和探查出血（BOP）。从每位患者收集GCF和血清样品，并通过酶联免疫吸附测定法分析FOLR1水平。结果在牙龈炎和牙周炎组中，GCF的FOLR1值高于对照组（p <0.016）。两组之间的血清FOLR1水平无显着差异。GCF和BOP的FOLR1水平之间存在显着相关性（p <0.05）。结论我们的初步数据表明FOLR1在监测牙周疾病中无用。需要进一步的研究来阐明叶酸及其受体在牙周疾病发病机理中的作用，调节和功能。