BACKGROUND Pulpotomy is one of the most widely used methods in preserving vital pulp in teeth, which is of great significance in achieving continue root formation in immature permanent teeth suffering from dental caries or trauma. The aim of this meta-analysis and systemic review is to synthesize the available evidences to compare different pulpotomy dressing agents for pulpotomy treatment in immature permanent teeth. METHODS Electronic databases including MEDLINE (via Pubmed), EMBASE, the Cochrane library (CENTRAL) and the clinicaltrials.gov database were searched. The references of all included articles or relevant reviews were cross-checked. Only randomized controlled trials (RCTs) comparing two or more pulp dressing agent in permanent teeth with open apex would be included. Also, the studies should have at least 6 months of follow-up, report clinical and radiographic success in detail and publish in English. RESULTS Five RCTs were included for a systematic review, and all of them had a high risk of bias. There is little difference in success rate between mineral trioxide aggregate (MTA) and calcium hydroxide (CH) at 6-month follow-up (risk ratio (RR) 1; 95% confidence interval (CI) 0.94 to 1.06) and 12-month follow-up (RR 1.04; 95% CI 0.96 to 1.13). There is no difference between MTA versus platelet-rich fibrin and MTA versus calcium-enriched mixture (CEM). There is only weak evidence of increased success rate in using MTA and triple antibiotic paste (TAP) rather than abscess remedy. CONCLUSIONS Based on the present evidence, similar success rates with MTA were found between the dressing agents CH, CEM, RPF and TAP as pulpotomy-dressing agents in the treatment of immature permanent teeth. More high-quality RCTs are needed in this field in future studies.

中文翻译：

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未成熟恒牙牙髓切开术的材料：系统评价和荟萃分析。

背景技术切开牙髓术是在牙齿中保存重要牙髓的最广泛使用的方法之一，这对于在患有龋齿或创伤的未成熟恒牙中实现持续的牙根形成具有重要意义。这项荟萃分析和系统综述的目的是综合现有证据，以比较不同的牙髓切开术治疗剂用于不成熟恒牙的牙髓切开术治疗。方法搜索包括MEDLINE（通过Pubmed），EMBASE，Cochrane库（CENTRAL）和Clinicaltrials.gov数据库在内的电子数据库。所有包含的文章或相关评论的参考文献均经过交叉检查。仅包括比较两种或两种以上恒牙恒牙开放中牙髓修整剂的随机对照试验（RCT）。此外，研究应至少随访6个月，详细报告临床和放射学上的成功，并以英文发表。结果纳入了5个RCT进行系统评价，所有这些RCT都有很高的偏倚风险。在6个月的随访中（风险比（RR）1； 95％置信区间（CI）0.94至1.06）和12个月的随访中，三氧化二矿骨料（MTA）和氢氧化钙（CH）的成功率差异不大。随访（RR 1.04; 95％CI 0.96至1.13）。MTA与富含血小板的血纤蛋白之间以及MTA与富含钙的混合物（CEM）之间没有差异。只有很少的证据显示使用MTA和三联抗生素糊剂（TAP）而不是脓肿可以提高成功率。结论根据目前的证据，在敷料剂CH，CEM，RPF和TAP作为不成熟恒牙治疗的切髓治疗剂。在以后的研究中，该领域需要更多高质量的RCT。