Protein intake is important for the recovery of the immune system, physical strength, and wound healing after surgery. Sarcopenia is associated with a poor prognosis when compared to patients without sarcopenia in cancer patients. Recently, edible insects, such as mealworms, have been recognized as having a high protein content. In this study, we will evaluate the effect of nutritional status and immune function change based on a patient’s ingestion of mealworms after hepatobiliary pancreatic surgery. This is a prospective, two-armed, phase III study investigating the effect of mealworm improving nutrition and immune status in patients after hepatobiliary pancreatic surgery. In the trial group, the patients will be provided with mealworms for 2 months after surgery. In the control group, patients will be provided with grain powder for 2 months after surgery. The target for accrual is 168 patients. We divided in to three groups according to the type of surgery. The primary endpoint is to evaluate body cell mass index 2 months postoperatively. Secondary endpoints include other body composition changes as well as nutrition index and immune function change. We expect that ingestion of mealworms can effectively improve the nutritional status and enhance the immune function. Mealworm can be used effectively for nutritional management of patients after surgery. Clinicaltrials.gov NCT03201926 Registered June 28, 2017, retrospectively registered.

中文翻译：

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使用黄粉虫进行无效食品的临床应用及营养状况和免疫功能评估：一项随机、双盲、安慰剂对照试验的研究方案

蛋白质摄入对于免疫系统的恢复、体力和手术后伤口的愈合很重要。与癌症患者中没有肌肉减少症的患者相比，肌肉减少症与预后不良有关。最近，食用昆虫，如粉虫，已被认为具有高蛋白质含量。在这项研究中，我们将根据患者在肝胆胰腺手术后摄入粉虫来评估营养状况和免疫功能变化的影响。这是一项前瞻性、双臂、III 期研究，调查黄粉虫改善肝胆胰手术后患者营养和免疫状态的作用。在试验组中，患者将在术后2个月内提供粉虫。在对照组中，术后2个月为患者提供谷粉。招募的目标是 168 名患者。我们根据手术类型分为三组。主要终点是术后 2 个月评估体细胞质量指数。次要终点包括其他身体成分变化以及营养指数和免疫功能变化。我们预计，食用黄粉虫可以有效改善营养状况，增强免疫功能。黄粉虫可有效用于术后患者的营养管理。Clinicaltrials.gov NCT03201926 2017 年 6 月 28 日注册，回顾性注册。次要终点包括其他身体成分变化以及营养指数和免疫功能变化。我们预计，食用黄粉虫可以有效改善营养状况，增强免疫功能。黄粉虫可有效用于术后患者的营养管理。Clinicaltrials.gov NCT03201926 2017 年 6 月 28 日注册，回顾性注册。次要终点包括其他身体成分变化以及营养指数和免疫功能变化。我们预计，食用黄粉虫可以有效改善营养状况，增强免疫功能。黄粉虫可有效用于术后患者的营养管理。Clinicaltrials.gov NCT03201926 2017 年 6 月 28 日注册，回顾性注册。