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Iron deposition in Parkinson’s disease by quantitative susceptibility mapping
BMC Neuroscience ( IF 2.4 ) Pub Date : 2019-05-22 , DOI: 10.1186/s12868-019-0505-9
Qiqi Chen 1 , Yiting Chen 2 , Yue Zhang 1 , Furu Wang 1 , Hongchang Yu 1 , Caiyuan Zhang 1 , Zhen Jiang 1 , Weifeng Luo 2
Affiliation  

BackgroundPatients with Parkinson’s disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia nigra (SN) and other deep gray matter nuclei of PD patients using quantitative susceptibility mapping (QSM) and its clinical relationship, and to explore whether there is a gradient of iron deposition pattern in globus pallidus (GP)–fascicula nigrale (FN)–SN pathway.MethodsThirty-three PD patients and 26 age- and sex-matched healthy volunteers (HVs) were included in this study. Subjects underwent brain MRI and constructed QSM data. The differences in iron accumulation in the deep gray matter nuclei of the subjects were compared, including the PD group and the control group, the early-stage PD (EPD) group and the late-stage PD (LPD) group. The iron deposition pattern of the GP–FN–SN pathway was analyzed.ResultsThe PD group showed increased susceptibility values in the FN, substantia nigra pars compacta (SNc), internal globus pallidus (GPi), red nucleus (RN), putamen and caudate nucleus compared with the HV group (P < 0.05). In both PD and HV group, iron deposition along the GP–FN–SN pathway did not show an increasing gradient pattern. The SNc, substantia nigra pars reticulata (SNr) and RN showed significantly increased susceptibility values in the LPD patients compared with the EPD patients.ConclusionPD is closely related to iron deposition in the SNc. The condition of PD patients is related to the SNc and the SNr. There is not an increasing iron deposition gradient along the GP–FN–SN pathway. The source and mechanism of iron deposition in the SN need to be further explored, as does the relationship between the iron deposition in the RN and PD.

中文翻译:

通过定量磁化率映射研究帕金森病中的铁沉积

背景帕金森病 (PD) 患者的脑铁水平升高,尤其是在黑质纹状体多巴胺能系统中。本研究的目的是利用定量磁敏图(QSM)评估PD患者黑质(SN)和其他深部灰质核中的铁沉积及其临床关系,并探讨铁沉积是否存在梯度。苍白球(GP)-黑体束(FN)-SN 通路中的模式。方法 本研究包括 33 名 PD 患者和 26 名年龄和性别匹配的健康志愿者(HV)。受试者接受脑部 MRI 并构建 QSM 数据。比较受试者深部灰质核铁积累的差异,包括PD组和对照组,早期PD(EPD)组和晚期PD(LPD)组。分析了 GP-FN-SN 通路的铁沉积模式。 结果 PD 组显示 FN、黑质致密部 (SNc)、苍白球 (GPi)、红核 (RN)、壳核和尾状核的磁敏度值增加与 HV 组相比(P < 0.05)。在 PD 和 HV 组中,沿着 GP-FN-SN 途径的铁沉积没有显示出增加的梯度模式。与EPD患者相比,LPD患者SNc、黑质网状部(SNr)和RN的敏感性值显着升高。结论PD与SNc铁沉积密切相关。PD患者的病情与SNc和SNr有关。沿着 GP-FN-SN 路径没有增加铁沉积梯度。
更新日期:2019-05-22
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