BackgroundTraumatic brain injury (TBI) is a widespread public health problem and a signature injury of our military in modern conflicts. Despite the long-term effects of even mild brain injuries, an effective treatment remains elusive. Coffee and several of its compounds, including caffeine, have been identified as having neuroprotective effects in studies of neurodegenerative disease. Given the molecular similarities between TBI and neurodegenerative disease, we have devised a study to test a nanocoffee extract in the treatment of a mouse model of mild TBI.ResultsAfter a single injury and two subsequent injections of nanocoffee, we identified treatment as being associated with improved behavioral outcomes, favorable molecular signaling changes, and dendritic changes suggestive of improved neuronal health.ConclusionsWe have identified coffee extracts as a potential viable multifaceted treatment approach to target the secondary injury associated with TBI.

中文翻译：

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模型创伤性脑损伤和纳米咖啡颗粒治疗后的行为、蛋白质和树突变化

背景创伤性脑损伤 (TBI) 是一个普遍存在的公共卫生问题，也是现代冲突中我军的标志性伤害。尽管即使是轻微的脑损伤也会产生长期影响，但有效的治疗方法仍然难以捉摸。在神经退行性疾病的研究中，咖啡及其几种化合物，包括咖啡因，已被确定为具有神经保护作用。鉴于 TBI 和神经退行性疾病之间的分子相似性，我们设计了一项研究来测试纳米咖啡提取物在治疗轻度 TBI 小鼠模型中的作用。行为结果、有利的分子信号变化和树突状变化表明神经元健康状况有所改善。