BACKGROUND The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis. METHODS We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (Passociation) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models. RESULTS Compared with the negative controls, no statistically significant difference in the odds of psoriasis was detected for the cases under any genetic models (BH adjusted Passociation > 0.05). We also performed subgroup meta-analyses by the source of controls, ethnicity, country, Hardy-Weinberg equilibrium, and genotyping method. Similar results were observed in most subgroup meta-analyses (BH adjusted Passociation > 0.05). Besides, data of Begg's and Egger's tests excluded the significant publication bias; while the sensitivity analysis data further indicated the statistical reliability of our pooling results. CONCLUSION The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.

中文翻译：

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关于人维生素D受体变异体对牛皮癣几率的影响的汇总分析。

背景技术本研究旨在通过更新的荟萃分析，科学调查人类维生素D受体（VDR）基因中四种多态性（rs7975232，rs1544410，rs2228570和rs731236）的遗传效应对银屑病的几率。方法我们搜索了八个数据库，并筛选了研究以进行汇总。最后，纳入了总共18项符合条件的病例对照研究。在等位基因，纯合子，杂合子，显性，隐性和携带者模型下，计算了BH（Benjamini＆Hochberg）调整后的关联P值（Passociation）和奇数比（OR）以及相应的95％置信区间（CI）。结果与阴性对照相比，在任何遗传模型下（BH调整后的Passociation> 0.05），银屑病几率均无统计学差异。我们还通过控制源，种族，国家，Hardy-Weinberg平衡和基因分型方法进行了亚组荟萃分析。在大多数亚组荟萃分析中观察到了相似的结果（BH调整后的Passociation> 0.05）。此外，Begg和Egger检验的数据排除了显着的出版偏倚。而敏感性分析数据进一步表明了我们合并结果的统计可靠性。结论当前可获得的数据未能支持VDR rs7975232，rs1544410，rs2228570和rs731236多态性与牛皮癣易感性之间的牢固关联，这仍需要更多病例对照研究的支持。在大多数亚组荟萃分析中观察到了相似的结果（BH调整后的Passociation> 0.05）。此外，Begg和Egger检验的数据排除了显着的出版偏倚。而敏感性分析数据进一步表明了我们合并结果的统计可靠性。结论当前可获得的数据未能支持VDR rs7975232，rs1544410，rs2228570和rs731236多态性与牛皮癣易感性之间的牢固关联，这仍需要更多病例对照研究的支持。在大多数亚组荟萃分析中观察到了相似的结果（BH调整后的Passociation> 0.05）。此外，Begg和Egger检验的数据排除了显着的出版偏倚。而敏感性分析数据进一步表明了我们合并结果的统计可靠性。结论当前可获得的数据未能支持VDR rs7975232，rs1544410，rs2228570和rs731236多态性与牛皮癣易感性之间的牢固关联，这仍需要更多病例对照研究的支持。