BACKGROUND Mannose-binding lectin (MBL) deficiency may increase risk of respiratory tract infection in adults unselected for IgG or IgG subclass levels. In a retrospective study, we sought to determine associations of serum MBL levels with clinical and laboratory characteristics of unrelated non-Hispanic white adults at diagnosis of IgG subclass deficiency (IgGSD). We computed the correlation of first and second MBL levels expressed as natural logarithms (ln) in a patient subgroup. We compared these characteristics of all adults with and without MBL ≤50 ng/mL: age; sex; body mass index; upper/lower respiratory tract infection; diabetes; autoimmune condition(s); atopy; other allergy; corticosteroid therapy; and subnormal serum IgG subclasses, IgA, and IgM. We performed logistic regression on MBL ≤50 ng/mL (dichotomous) using the three independent variables with the lowest values of p in univariate comparisons. RESULTS There were 219 patients (mean age 51 ± 13 y; 82.5% women). Thirty-six patients (16.4%) had MBL ≤50 ng/mL. Two MBL measurements were available in 14 patients. The median interval between the first and second measurements was 125 d (range 18-1031). For ln-transformed data, we observed adjusted r2 = 0.9675; Pearson correlation coefficient 0.9849; and p < 0.0001. Characteristics of patients with and without MBL ≤50 ng/mL did not differ significantly in univariate comparisons. We performed a regression on MBL ≤50 ng/mL using: subnormal IgM (p = 0.0565); upper respiratory tract infection (p = 0.1094); and body mass index (p = 0.1865). This regression revealed no significant associations. CONCLUSIONS We conclude that the proportion of the present IgGSD patients with serum MBL ≤50 ng/mL is similar to that of healthy European adults. MBL ≤50 ng/mL was not significantly associated with independent variables we studied.

中文翻译：

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219名IgG亚类缺陷成人的甘露糖结合凝集素的临床和实验室关联。

背景技术甘露糖结合凝集素（MBL）缺乏症可能会增加未选择IgG或IgG亚类水平的成年人呼吸道感染的风险。在一项回顾性研究中，我们试图确定血清MBL水平与无关的非西班牙裔白人成年人在诊断IgG亚类缺乏症（IgGSD）时的临床和实验室特征之间的关联。我们计算了患者亚组中以自然对数（ln）表示的第一和第二MBL水平的相关性。我们比较了MBL≤50 ng / mL和不存在MBL的所有成年人的这些特征：年龄；性别; 体重指数 上/下呼吸道感染；糖尿病; 自身免疫性疾病；特应性 其他过敏；皮质类固醇疗法；以及血清IgG亚类，亚正常水平，IgA和IgM。我们使用单变量比较中p值最低的三个自变量对MBL≤50ng / mL（二分法）进行了逻辑回归。结果219例患者（平均年龄51±13岁；女性占82.5％）。三十六例（16.4％）的MBL≤50ng / mL。有14位患者进行了两次MBL测量。第一次和第二次测量之间的中位间隔为125 d（范围18-1031）。对于ln转换的数据，我们观察到调整后的r2 = 0.9675；皮尔逊相关系数0.9849；并且p <0.0001。MBL≤50 ng / mL的患者和没有MBL的患者的特征在单因素比较中无显着差异。我们对MBL≤50ng / mL进行了回归分析：上呼吸道感染（p = 0.1094）; 和体重指数（p = 0.1865）。这种回归显示没有显着的关联。结论我们得出结论，目前血清MBL≤50ng / mL的IgGSD患者的比例与健康的欧洲成年人相似。MBL≤50ng / mL与我们研究的自变量没有显着相关。