BACKGROUND Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n = 67) and non-functioning (NF) pituitary adenoma (n = 67) were recruited from the outpatient and inpatient patient department of The First Affiliated Hospital, Jinan University from August 2015 to August 2017. Thyroid ultrasonography was performed using an ultrasound system. The cytopathological results of fine-needle aspiration biopsy were analyzed by a pathologist according to the Bethesda system. Twenty-one patients with GH-secreting adenoma and thyroid disease underwent transsphenoidal pituitary adenoma resection and were followed up for 1 year. RESULTS The prevalence of thyroid disease increased in the GH-secreting adenoma group compared with that in the NF pituitary adenoma group. The number of hypoechoic, isoechogenic, heterogeneous, and vascular thyroid nodules increased in patients with GH-secreting adenoma plus thyroid disease compared with that in patients with NF pituitary adenoma plus thyroid disease. Finally, we found significant decreases in the morphology of solid nodules and significant increases in the morphology of cystic nodules after surgery compared with those before surgery in the cured group. Moreover, the numbers of heterogeneous and vascular thyroid nodules decreased significantly after surgery compared with those before surgery in the cured group. However, the characteristics of the thyroid nodules did not change after surgery compared with those before surgery in the non-cured group. CONCLUSIONS The numbers of hypoechoic, isoechoic, heterogeneous, and vascular thyroid nodules increased in patients with GH-secreting adenomas. In these patients, surgery resulted in significant changes from solid to cystic nodules and also reduced the numbers of heterogeneous and vascular thyroid nodules.

中文翻译：

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评估生长激素分泌腺瘤患者的甲状腺特征。

背景技术肢端肥大症与甲状腺疾病高度相关。但是，尚未完全阐明患有肢端肥大症并伴有甲状腺疾病的个体的甲状腺结节的临床特征。方法总共从济南市第一附属医院门诊和住院患者中招募了134名连续分泌生长激素（GH）的腺瘤（n = 67）和无功能（NF）垂体腺瘤（n = 67）的参与者。于2015年8月至2017年8月在大学期间就读。甲状腺超声检查是使用超声系统进行的。病理学家根据Bethesda系统分析了细针穿刺活检的细胞病理学结果。对21例生长激素分泌腺瘤和甲状腺疾病的患者行经蝶窦垂体腺瘤切除术，随访1年。结果与NF垂体腺瘤组相比，分泌GH的腺瘤组的甲状腺疾病患病率增加。与NF垂体腺瘤加甲状腺疾病患者相比，GH分泌腺瘤加甲状腺疾病患者的低回声，等回声，异质性和血管甲状腺结节数目增加。最后，我们发现与治愈组相比，手术后的实性结节形态明显减少，囊性结节形态明显增加。而且，治愈组与手术前相比，甲状腺异种和血管甲状腺结节的数量明显减少。但是，与未治愈组相比，手术后甲状腺结节的特征没有改变。结论分泌GH的腺瘤患者的低回声，等回声，异质性和血管甲状腺结节数目增加。在这些患者中，手术导致从实性结节到囊性结节的显着变化，并且减少了异种和血管甲状腺结节的数量。分泌GH的腺瘤患者的甲状腺和血管甲状腺结节增加。在这些患者中，手术导致从实性结节到囊性结节的显着变化，并且减少了异种和血管甲状腺结节的数量。分泌GH的腺瘤患者的甲状腺和血管甲状腺结节增加。在这些患者中，手术导致从实性结节到囊性结节的显着变化，并且减少了异种和血管甲状腺结节的数量。