Abnormal levels of liver enzymes, particularly aminotransferases, are prognostic features of non-alcoholic fatty liver disease (NAFLD). Considering the important role of dietary intakes in development of NAFLD, we aimed to determine possible association of unhealthy foods (fast foods, soft drinks, sweet and salty snacks) consumption with elevated levels of aminotransferases. This cross-sectional study was conducted within the framework of sixth phase of the Tehran Lipid and Glucose Study (2014–2017), on 187 adult men and 249 adult women (19–70 y). Usual intakes of unhealthy foods (kcal/week) were measured using a validated semi-quantitative 147-items food frequency questionnaire. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) were measured. Multivariable logistic regression models were used to estimate the odds of elevated aminotransferases in each tertile of energy-dense unhealthy foods. Mean age of participants was 44.44 ± 15.09 years, 43% of participants were men. Higher consumption of fast foods (> 11.39% kcal/week) was associated with elevated ALT to AST ratio (OR: 3.27; 95% CI: 1.90–5.63) and elevated ALT (OR: 2.74; 95% CI: 1.57–4.76). Also, each 1 SD increased energy intakes from fast foods was related to increased chance of having elevated ALT and ALT to AST ratio by 35% (OR: 1.35; 95% CI: 1.08–1.68, OR: 1.35; 95% CI: 1.10–1.66, respectively). There was no significant association between consumption of soft drinks, sweet or salty snacks and elevated aminotransferases. Higher intakes of energy from fast foods seems to be associated with an elevated serum levels of ALT and ALT to AST ratio, as indicators of development of NAFLD.

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与不健康食品摄入相关的血清转氨酶水平升高：德黑兰脂质和葡萄糖研究

肝酶，特别是转氨酶的异常水平是非酒精性脂肪肝疾病（NAFLD）的预后特征。考虑到饮食摄入量在NAFLD发生中的重要作用，我们旨在确定不健康食品（快餐，软饮料，甜咸食品）的摄入与氨基转移酶水平升高之间的可能联系。这项横断面研究是在德黑兰脂质和葡萄糖研究的第六阶段（2014-2017年）的框架内进行的，研究对象为187名成年男性和249名成年女性（19-70岁）。使用经过验证的半定量147项食物频率问卷来测量不健康食物的平常摄入量（千卡/周）。测量血清丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST）水平。使用多变量logistic回归模型估算能量密集的不健康食品的每三分位数中转氨酶升高的几率。参加者的平均年龄为44.44±15.09岁，其中43％为男性。快餐消费量的增加（> 11.39％kcal /周）与ALT / AST比升高（OR：3.27； 95％CI：1.90-5.63）和ALT升高（OR：2.74； 95％CI：1.57-4.76）相关。 。同样，快餐食品每摄入1 SD能量，就会使ALT和ALT与AST比率升高的机会增加35％（或：1.35； 95％可信区间：1.08–1.68，或：1.35； 95％可信区间：1.10） –1.66）。软饮料，甜或咸的零食与转氨酶升高之间没有显着关联。