BACKGROUND Nigella sativa or commonly known as black seed or black cumin is one of the most ubiquitous complementary medicine. Epithelial to mesenchymal transition (EMT) of type 2 is defined by the balance between wound healing and tissue fibrosis, which is dependent to the state of inflammation. This systematic review is conducted to provide an overview regarding the reported effect of Nigella sativa and its bioactive compound on the type 2 EMT. METHODS A search was done in EBSCOHOST, OVID and SCOPUS database to obtain potentially relevant articles that were published between 1823 and August 2019. This review includes studies that focus on the effect of Nigella sativa and its bioactive compound on the events related to type 2 EMT. RESULTS A total of 1393 research articles were found to be potentially related to the effect of Nigella sativa and its bioactive compound, thymoquinone on Type 2 EMT. After screening was done, 22 research articles met inclusion criteria and were included in this review. Majority of the studies, reported better wound healing rate or significant prevention of tissue inflammation and organ fibrosis following Nigella sativa or thymoquinone treatments. In terms of wound healing, studies included reported progression of EMT related pathological changes after treatment with Nigella sativa or thymoquinone. Alternatively, in terms of fibrosis and inflammation, studies included reported reversal of pathological changes related to EMT after treatment with Nigella sativa or thymoquinone. CONCLUSION Through this review, Nigella sativa and thymoquinone have been associated with events in Type 2 EMT. They have been shown to promote wound healing, attenuate tissue inflammation, and prevent organ fibrosis via regulation of the EMT process.

中文翻译：

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黑种草及其生物活性化合物对 2 型上皮间质转化的影响：系统评价。

背景黑种草或俗称黑籽或黑孜然是最普遍的补充药物之一。2 型上皮间质转化 (EMT) 是由伤口愈合和组织纤维化之间的平衡定义的，这取决于炎症状态。本系统综述旨在概述黑种草及其生物活性化合物对 2 型 EMT 的影响。方法 在 EBSCOHOST、OVID 和 SCOPUS 数据库中进行搜索，以获得 1823 年至 2019 年 8 月期间发表的潜在相关文章。本综述包括重点关注黑种草及其生物活性化合物对 2 型 EMT 相关事件的影响的研究。结果 总共发现 1393 篇研究文章可能与黑种草及其生物活性化合物百里醌对 2 型 EMT 的影响有关。经过筛选，共有 22 篇研究文章符合纳入标准，纳入本次综述。大多数研究报告称，黑种草或百里醌治疗后，伤口愈合率更高，或显着预防组织炎症和器官纤维化。在伤口愈合方面，研究报告了黑种草或百里醌治疗后 EMT 相关病理变化的进展情况。另外，在纤维化和炎症方面，研究报告称，用黑种草或百里醌治疗后，与 EMT 相关的病理变化发生逆转。结论 通过本次综述，黑种草和百里醌与 2 型 EMT 事件相关。它们已被证明可以通过调节 EMT 过程促进伤口愈合、减轻组织炎症并预防器官纤维化。