当前位置: X-MOL 学术BMC Anesthesiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and vomiting, and pruritus in parturient undergoing cesarean section - a randomized control trial.
BMC Anesthesiology ( IF 2.2 ) Pub Date : 2019-09-14 , DOI: 10.1186/s12871-019-0847-y
Sylvanus Kampo 1, 2 , Alfred Parker Afful 1 , Shiraj Mohammed 2 , Michael Ntim 3 , Alexis D B Buunaaim 4 , Thomas Winsum Anabah 1, 2
Affiliation  

BACKGROUND Postoperative Nausea and Vomiting (PONV) is a dreadful and uncomfortable experience that significantly detracts patients' quality of life after surgery. This study aimed to examine the antiemetic effect of a single sub-hypnotic dose of propofol as prophylaxis for PONV. METHOD In this prospective, double-blind, randomized control trial, 345 parturients presented for elective cesarean section at the Obstetric unit of Tamale Teaching Hospital were recruited. Each recruited parturient was randomly assigned to one of three groups; Propofol group (n = 115) represented those who received propofol 0.5 mg/kg, Metoclopramide group (n = 115) represented those who received metoclopramide 10 mg and, Control group (n = 115) represented those who received 0.9% saline. Spinal anesthesia with 0.5% hyperbaric bupivacaine 7.5-10 mg, and intrathecal morphine 0.2 mg was employed for the anesthesia. RESULTS The data indicate that 108 (93.9%) parturients from the control group, 10 (8.7%) from the propofol group and 8 (7.0%) from the metoclopramide group experienced some incidence of PONV. There was no significant difference in the incidence of PONV (nausea, vomiting, and none) between the propofol and the metoclopramide groups (P = 0.99; 0.31; and 0.35 respectively). Parturients who received antiemetic agents were 105 (97.2%), 1 (10.0%) and 3 (37.5%) from the control, propofol and metoclopramide groups respectively. The data indicated that 98 (85.2%) parturients from the control, 3 (2.6%) from propofol group, and 100 (87.0%) from the metoclopramide group experienced some levels of pruritus. There was a significant difference in the incidence of pruritus (mild, moderate, and no pruritus) between the metoclopramide and propofol groups (P <  0.01; P <  0.01; and P <  0.01 respectively). CONCLUSION A sub-hypnotic dose of propofol is effective as metoclopramide in the prevention of PONV in parturient undergoing cesarean section under spinal anesthesia with intrathecal morphine. Sub-hypnotic dose of propofol significantly reduces the incidence of postoperative pruritus following intrathecal morphine use. TRIAL REGISTRATION Current control trial, registered at ISRCTN trial registry: ISRCTN15475205 . Date registered: 03/04/2019. Retrospectively registered.

中文翻译:

亚催眠剂量的异丙酚作为止吐剂的预防措施可减轻鞘内吗啡引起的术后恶心,呕吐和剖宫产产妇的瘙痒,这是一项随机对照试验。

背景技术术后恶心和呕吐(PONV)是一种可怕且令人不适的经历,极大地降低了患者术后的生活质量。这项研究旨在检查单次催眠剂量的异丙酚作为PONV预防剂的止吐作用。方法在这项前瞻性,双盲,随机对照试验中,招募了345名在Tamale教学医院产科进行选择性剖宫产的产妇。每个新招募的产妇被随机分配到三组中的一组。丙泊酚组(n = 115)代表接受异丙酚0.5 mg / kg的人群,甲氧氯普胺组(n = 115)代表接受甲氧氯普胺10 mg的人群,对照组(n = 115)代表接受0.9%生理盐水的人群。用0.5%高压布比卡因7.5-10 mg进行的脊髓麻醉,鞘内注射吗啡0.2 mg麻醉。结果数据表明,对照组的108名(93.9%)产妇,丙泊酚组的10名(8.7%)和甲氧氯普胺组的8名(7.0%)发生了PONV。丙泊酚和甲氧氯普胺组之间PONV的发生率无明显差异(恶心,呕吐和无)(分别为P = 0.99、0.31和0.35)。接受止吐药的产妇分别为对照组,丙泊酚和甲氧氯普胺组的105名(97.2%),1名(10.0%)和3名(37.5%)。数据显示,对照组有98(85.2%)个产妇,丙泊酚组有3个(2.6%),甲氧氯普胺组有100个(87.0%)经历了一定程度的瘙痒。瘙痒的发生率有显着差异(轻度,中度,甲氧氯普胺和异丙酚组之间无瘙痒(分别为P <0.01,P <0.01和P <0.01)。结论亚催眠剂量的异丙酚在鞘内注射吗啡对脊髓麻醉下剖宫产的产妇预防PONV有效。亚催眠剂量的异丙酚显着降低鞘内使用吗啡后术后瘙痒的发生率。试验注册当前的对照试验,已在ISRCTN试验注册处注册:ISRCTN15475205。注册日期:03/04/2019。追溯注册。结论亚催眠剂量的异丙酚在鞘内注射吗啡对脊髓麻醉下剖宫产的产妇预防PONV有效。亚催眠剂量的异丙酚显着降低鞘内使用吗啡后术后瘙痒的发生率。试验注册当前的对照试验,已在ISRCTN试验注册处注册:ISRCTN15475205。注册日期:03/04/2019。追溯注册。结论亚催眠剂量的异丙酚在鞘内注射吗啡对脊髓麻醉下剖宫产的产妇预防PONV有效。亚催眠剂量的异丙酚显着降低鞘内使用吗啡后术后瘙痒的发生率。试验注册当前的对照试验,已在ISRCTN试验注册处注册:ISRCTN15475205。注册日期:03/04/2019。追溯注册。
更新日期:2019-11-28
down
wechat
bug