Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The TH17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation. The aim of our study was to evaluate the association between genetic variants in IL17 pathway genes with asthma and atopy markers. Genotyping was performed using a commercial panel in 1245 participants of SCAALA cohort. The study included 91 SNVs in IL-17 pathway genes. Logistic regressions for asthma and atopy markers were performed using PLINK 1.9. In silico analyses were performed using rSNPbase, RegulomeDB, and Gtex portal for in silico gene expression. The T allele of rs1974226 in IL17A was positively associated with asthma (OR: 1.37; 95% CI 1.02–1.82). Also, the T allele of rs279548 was positively associated with asthma (OR: 1.30; 95% CI 1.02–1.64), atopy (OR: 1.62; 95% CI 1.05–2.50) and increased expression of the IL17RC in lung and whole blood tissues. The others genetic variants in the IL17 pathways genes were associated with both protection and risk for asthma development as well as with IgE levels. The genetic variants in IL-17-related genes are associated with the atopic asthma phenotype and IgE production.

中文翻译：

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IL17 通路基因的变异与南美人群中的特应性哮喘和特应性产生者相关

哮喘是一种复杂的疾病，具有多种表型，可以影响其严重程度和对治疗的反应。TH17 淋巴细胞产生 IL-17A 和 IL17-F 细胞因子，可能在哮喘炎症中发挥作用。我们研究的目的是评估 IL17 通路基因的遗传变异与哮喘和特应性标志物之间的关联。使用商业小组对 SCAALA 队列的 1245 名参与者进行基因分型。该研究包括 IL-17 通路基因中的 91 个 SNV。使用 PLINK 1.9 对哮喘和特应性标记物进行逻辑回归。使用 rSNPbase、RegulomeDB 和 Gtex 门户进行计算机基因表达分析。IL17A 中 rs1974226 的 T 等位基因与哮喘呈正相关（OR：1.37；95% CI 1.02-1.82）。此外，rs279548 的 T 等位基因与哮喘（OR：1.30；95% CI 1.02–1.64）、特应性（OR：1.62；95% CI 1.05–2.50）以及肺和全血组织中 IL17RC 表达增加呈正相关。 。IL17 通路基因中的其他遗传变异与哮喘发展的保护和风险以及 IgE 水平相关。IL-17 相关基因的遗传变异与特应性哮喘表型和 IgE 产生相关。