Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related diseases. We aimed to explore whether sestrin2 was involved in asthma. Seventy-six subjects (44 in the asthma group, 32 in the control group) were recruited in this study. Plasma sestrin2 levels, peak expiratory flow (PEF), forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio were measured in controls and in asthmatics both during an exacerbation and when controlled after the exacerbation. The asthma group had a significant higher sestrin2 level than the control group (asthmatics during exacerbation, 1.75 ± 0.53 ng/mL vs. 1.32 ± 0.48 ng/mL, p < 0.001; asthmatics when controlled after the exacerbation, 1.56 ± 0.46 ng/mL vs. 1.32 ± 0.48 ng/mL, p = 0.021, respectively). In addition, sestrin2 was negatively correlated with FEV1% predicted and FEV1/FVC ratio in asthmatics during exacerbation (r = − 0.393, p = 0.008; r = − 0.379, p = 0.011; respectively). Moreover, negative correlations between sestrin2 and FEV1% predicted and FEV1/FVC ratio also existed in asthmatics when controlled after the exacerbation (r = − 0.543, p < 0.001; r = − 0.433, p = 0.003 respectively). More importantly, multiple linear regression analysis demonstrated that FEV1% predicted was independently associated with sestrin2 in asthmatics both during exacerbation and when controlled after the exacerbation. Sestrin2 is involved in asthma. Sestrin2 levels increase in asthmatics both during exacerbation and when controlled after the exacerbation. In addition, sestrin2 is independently associated with FEV1% predicted.

中文翻译：

---

Sestrin2 与哮喘有关：病例对照研究

哮喘是一种严重危害患者健康的慢性疾病。氧化应激与哮喘有关。作为一种氧化应激诱导蛋白，sestrin2 在氧化应激相关疾病中升高。我们旨在探索sestrin2是否与哮喘有关。本研究招募了 76 名受试者（哮喘组 44 名，对照组 32 名）。在哮喘发作期间和控制时测量对照组和哮喘患者的血浆 sestrin2 水平、呼气峰值流量 (PEF)、1 秒内用力呼气量 (FEV1) 预测百分比、用力肺活量 (FVC) 预测百分比和 FEV1/FVC 比值恶化后。哮喘组的 sestrin2 水平显着高于对照组（哮喘发作期间，1.75 ± 0.53 ng/mL vs. 1.32 ± 0.48 ng/mL，p < 0.001；哮喘发作后得到控制的哮喘患者，分别为 1.56 ± 0.46 ng/mL 和 1.32 ± 0.48 ng/mL，p = 0.021）。此外，在哮喘发作期间，sestrin2 与 FEV1% 预测值和 FEV1/FVC 比率呈负相关（分别为 r = - 0.393，p = 0.008；r = - 0.379，p = 0.011）。此外，在哮喘发作后得到控制时，sestrin2 和 FEV1% 预测值与 FEV1/FVC 比率之间也存在负相关（分别为 r = - 0.543，p < 0.001；r = - 0.433，p = 0.003）。更重要的是，多元线性回归分析表明，无论是在哮喘发作期间还是在发作后得到控制时，预测的 FEV1% 都与哮喘患者的 sestrin2 独立相关。Sestrin2 与哮喘有关。在哮喘发作期间和在发作后得到控制时，Sestrin2 水平在哮喘患者中都会增加。此外，sestrin2 与预测的 FEV1% 独立相关。