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Rapid and Efficient Construction of Indolizino[3,4,5‐ab]isoindole Skeletons by a Rhodium‐Catalyzed Tandem Reaction
Asian Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2019-12-05 , DOI: 10.1002/ajoc.201900660
Chang Liu 1 , Shaonan Wu 1 , Wan Sun 1 , Haifang Meng 1 , Siyang Xing 1 , Bolin Zhu 1
Affiliation  

A facile rhodium‐catalyzed tandem reaction of two molecules of acrylates with two molecules of 2‐phenylpyridines involving sequential C−H activation, Michael addition, [12+2] cycloaddition and oxidative aromatization has been described. A series of indolizino[3,4,5‐ab]isoindole compounds were efficiently afforded in good yields by the formation of two C−C bonds, two C=C bonds and one C−N bond.

中文翻译:

铑催化串联反应快速有效地构建吲哚并[3,4,5-ab]异吲哚骨架

已经描述了一种简单的铑催化的两分子丙烯酸酯与两分子的2-苯基吡啶的串联反应,涉及连续的CH活化,迈克尔加成,[12 + 2]环加成和氧化芳构化。通过形成两个C-C键,两个C = C键和一个C-N键,可以有效地以高收率有效地获得一系列indolizino [3,4,5- ab ]异吲哚化合物。
更新日期:2019-12-05
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