White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐body energy status and metabolism; it not only stores excess energy but also secretes various hormones and metabolites to regulate body energy balance. Healthy adipose tissue capable of expanding is needed for metabolic well‐being and to prevent accumulation of triglycerides to other organs. Mitochondria govern several important functions in the adipose tissue. We review the derangements of mitochondrial function in white adipose tissue in the obese state. Downregulation of mitochondrial function or biogenesis in the white adipose tissue is a central driver for obesity‐associated metabolic diseases. Mitochondrial functions compromised in obesity include oxidative functions and renewal and enlargement of the adipose tissue through recruitment and differentiation of adipocyte progenitor cells. These changes adversely affect whole‐body metabolic health. Dysfunction of the white adipose tissue mitochondria in obesity has long‐term consequences for the metabolism of adipose tissue and the whole body. Understanding the pathways behind mitochondrial dysfunction may help reveal targets for pharmacological or nutritional interventions that enhance mitochondrial biogenesis or function in adipose tissue.

中文翻译：

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健康和肥胖症中的白色脂肪组织线粒体代谢。

白色脂肪组织是人体最大的器官之一。它在全身能量状态和新陈代谢中起关键作用。它不仅可以储存多余的能量，还可以分泌各种激素和代谢产物来调节人体的能量平衡。能够健康成长的健康脂肪组织对于代谢健康和防止甘油三酸酯积聚到其他器官是必不可少的。线粒体控制着脂肪组织中的几个重要功能。我们审查肥胖状态下白色脂肪组织中线粒体功能的紊乱。白色脂肪组织中线粒体功能或生物发生的下调是肥胖相关代谢性疾病的主要驱动力。肥胖中受损的线粒体功能包括氧化功能以及通过募集和分化脂肪细胞祖细胞而使脂肪组织更新和扩大。这些变化会对全身代谢健康产生不利影响。肥胖中的白色脂肪组织线粒体功能异常对脂肪组织和整个身体的新陈代谢具有长期影响。了解线粒体功能障碍背后的途径可能有助于揭示可提高线粒体生物发生或脂肪组织功能的药理或营养干预措施的目标。