Neurogenesis is the process underlying the development of the highly evolved central nervous system (CNS) in vertebrates. Neurogenesis takes place by differentiation of specific Neural Precursor Cells in the neurogenic niche. The main objective of this review is to highlight the specific relationship between the brain cavities, and neurogenesis from neural precursors. Brain cavities and their content, Cerebrospinal Fluid (CSF), establish a key relation with the neurogenic "niche" because of the presence in this fluid of neurogenic signals able to control neural precursor cell behaviour, inducing precursor proliferation and neuronal differentiation. This influence seems to be ontogenically preserved, despite the temporal and spatial variations that occur throughout life. In order to better understand this concept, we consider three main life periods in the CSF-Neurogenesis interaction: The "Embryonic" period, which take place at the Neural Tube stage and extends from the isolation of the neural tube at the end of "neurulation" to the beginning of Choroid Plexus activity; the "Fetal" period, which includes the remaining developmental and the early postnatal stages; and the "Adult" period, which continues for the rest of adult life. Each period has specific characteristics in respect of CSF synthesis and composition, and the location, extension and neurogenic activity of the neurogenic niche. However, CSF interaction with the neurogenic niche is a common factor, which should be taken into account to better understand the ontogeny of neuron formation and replacement, as well as its potential role in the success or failure of therapies for the ageing, injured or diseased brain.

中文翻译：

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神经发生：与脑腔及其内容CSF内在联系的过程。

神经发生是脊椎动物高度进化的中枢神经系统（CNS）发展的基础过程。神经发生通过在神经原位中分化特定的神经前体细胞而发生。这篇综述的主要目的是强调脑腔和神经前体神经发生之间的特定关系。脑腔及其内容，即脑脊液（CSF）与神经源性“利基”建立了关键关系，因为在这种流体中存在能够控制神经前体细胞行为，诱导前体增殖和神经元分化的神经源性信号。尽管在整个生命中都发生了时间和空间上的变化，但这种影响似乎在本体上得以保留。为了更好地理解这个概念，我们考虑了CSF与神经发生相互作用的三个主要生命周期：“胚胎”期，发生在神经管阶段，从“神经末梢”的神经管隔离一直延伸到脉络膜活动开始; “胎儿”期，包括剩余的发育阶段和产后早期阶段；而“成人”期则持续到成年余生。每个时期在脑脊液的合成和组成以及神经源性利基的位置，延伸和神经源性活性方面都有特定的特征。但是，CSF与神经源性小生境的相互作用是一个共同因素，应将其考虑在内，以更好地了解神经元形成和置换的个体发育，