Organofluorines are widely used in a variety of applications, ranging from pharmaceuticals to pesticides and advanced materials. The widespread use of organofluorines also leads to its accumulation in the environment, and two major questions arise: how to synthesize and how to degrade this type of compound effectively? In contrast to a considerable number of easy-access chemical methods, milder and more effective enzymatic methods remain to be developed. In this review, we present recent progress on enzyme-catalyzed C–F bond formation and cleavage, focused on describing C–F bond formation enabled by fluorinase and C–F bond cleavage catalyzed by oxidase, reductase, deaminase, and dehalogenase.

中文翻译：

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酶催化的CF键的形成和裂解

有机氟广泛用于各种应用，从药物到农药和先进材料。有机氟的广泛使用也导致其在环境中的积累，并且出现了两个主要问题：如何合成和如何有效降解这类化合物？与大量易于使用的化学方法相反，温和，更有效的酶促方法仍有待开发。在这篇综述中，我们介绍了酶催化的C–F键形成和裂解的最新进展，重点介绍了由氟化酶和氧化酶，还原酶，脱氨酶和脱卤酶催化的C–F键裂解促成的C–F键形成。