The article describes the preparation and characterization of 3D-printed tablets with bicalutamide obtained using two-material co-extrusion-based fused deposition modeling (FDM). This method is a modification of typical two-material FDM where separate nozzles are used to print from two filaments. In this work we used a ZMorph® 3D printer with DualPro printhead which allows us to co-extrude two filaments through a single nozzle. This approach gives the opportunity to modify tablet properties in a wide range, especially the dissolution rate, by producing dosage forms with a complex design. The great advantage of this method is that switching between immediate dosage form and controlled release does not require any change in the 3D-printer set-up. We checked the accuracy of co-extrusion printing simply by weighing the amounts of soluble and insoluble material in the printed object as well as calculating the volumes of the printed objects from micro computed tomography (µ-CT) images. We printed several tablets with a different design including simple one-material tablets, two- and three-compartment tablets with various internal structure and composition of the printing path. The dissolution tests were conducted in sink and non-sink conditions. We obtained tablets with desired bicalutamide dissolution profiles, i.e. immediate, controlled, and combined. The formation of spatial matrix slows down the dissolution in controlled and combined release bicalutamide tablets what was confirmed by µ-CT analysis before and after dissolution.

中文翻译：

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加快速度，减慢速度……这是比卡鲁胺从3D打印片剂中释放的问题。

该文章介绍了使用比卡鲁胺使用两种材料基于共挤出的熔融沉积建模（FDM）获得的3D打印片剂的制备和表征。此方法是对典型的两种材料的FDM的改进，其中使用单独的喷嘴从两条灯丝进行打印。在这项工作中，我们使用了具有DualPro打印头的ZMorph®3D打印机，该打印机可让我们通过单个喷嘴共挤出两根细丝。通过生产具有复杂设计的剂型，这种方法使人们有机会在广泛的范围内改变片剂的性能，尤其是溶出度。该方法的最大优点是，在即刻剂型和​​控释之间切换无需对3D打印机设置进行任何更改。我们仅通过称量打印对象中可溶和不溶性材料的量，并根据微型计算机断层扫描（µ-CT）图像计算打印对象的体积即可检查共挤出打印的准确性。我们以几种不同的设计印刷了数位板，包括简单的一种材料的数位板，具有不同内部结构和印刷路径组成的两室和三室型数位板。溶出度测试在水槽和非水槽条件下进行。我们获得了具有理想比卡鲁胺溶出曲线的片剂，即即刻，可控和组合。空间基质的形成减慢了比卡鲁胺控释和联合释放比卡鲁胺片的溶出度，这在溶出之前和之后均通过µ-CT分析得到了证实。