PURPOSE We aimed to investigate the magnetic resonance imaging (MRI) features and clinicopathologic factors with recurrence of triple-negative breast cancer (TNBC). PATIENTS AND METHODS We identified 281 patients with 288 surgically confirmed TNBC lesions who underwent pretreatment MRI between 2009 and 2015. The presence of intratumoral high signal on T2-weighted images, high-signal rim on diffusion-weighted images (DWI), and rim enhancement on the dynamic contrast-enhanced MRI and clinicopathological data were collected. Cox proportional analysis was performed. RESULTS Of the 288 lesions, 36 (12.5%) recurred after a median follow-up of 18 months (range, 3.6-68.3 months). Rim enhancement (hazard ratio [HR] = 3.15; 95% confidence interval [CI] = 1.01, 9.88; p = .048), and lymphovascular invasion (HR = 2.73, 95% CI = 1.20, 6.23; p = .016) were independently associated with disease recurrence. While fibroglandular volume, background parenchymal enhancement, intratumoral T2 high signal, and high-signal rim on DWI, were not found to be risk factors for recurrence. CONCLUSION Pretreatment MRI features may help predict a high risk of recurrence in patients with TNBC.

中文翻译：

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三阴性乳腺癌：治疗前的磁共振成像特征和与复发相关的临床病理因素。

目的我们旨在研究三阴性乳腺癌（TNBC）复发的磁共振成像（MRI）特征和临床病理因素。患者与方法我们确定了281例经手术确认的TNBC病变的281例患者，这些患者在2009年至2015年之间接受了MRI预处理。T2加权图像上存在瘤内高信号，弥散加权图像（DWI）上存在高信号边缘，并且边缘增强进行动态对比增强MRI检查并收集临床病理资料。进行Cox比例分析。结果在288个病灶中，中位随访18个月（范围3.6-68.3个月）后复发了36例（12.5％）。轮缘增强（危险比[HR] = 3.15； 95％置信区间[CI] = 1.01，9.88; p = .048）和淋巴管浸润（HR = 2.73，95％CI = 1.20，6.23； p =。016）与疾病复发独立相关。虽然未发现纤维支原体体积，背景实质增强，肿瘤内T2高信号和DWI上的高信号边缘是复发的危险因素。结论MRI预处理可能有助于预测TNBC患者的高复发风险。