The airways and lungs of vertebrates are an entrance way for several microbial pathogens. Cetaceans present an upper and lower respiratory anatomy that allows the rapid flow of large air volumes, which may lead to high susceptibility to respiratory infections. Mortality and stranding rate of Cetaceans increased dramatically, so wide the knowledge about the immune system and specific antibodies identifying immune cells populations, is of fundamental importance to monitor and document cetacean health. The aim of this study was to identify the localization of dendritic cells marked by Langerin/CD207 in airways, lungs and associated lymph nodes, of the striped dolphin Stenella coeruleoalba. Samples of trachea, bronchi, lungs and lung-associated lymph nodes were obtained from a stranded adult male of Stenella coeruleoalba. Our results showed abundant lymphoid aggregates (LAs) in the lung of S. ceruleoalba. Langerhans-like dendritic cells were well distributed along the epithelium and interstitium of respiratory tract and in associated lymph nodes. The present study deepens the knowledge about the cetacean's immune system and report about the exploitability of a commercial antibody (Langerin/CD207) for cetacean species.

中文翻译：

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Langerin / CD207在搁浅的条纹海豚（Stenella coeruleoalba）的气道，肺和相关淋巴结中的表达。

脊椎动物的气道和肺是几种微生物病原体的进入途径。鲸类动物的上，下呼吸道解剖结构使大风量迅速流动，这可能导致呼吸道感染的高度易感性。鲸类动物的死亡率和搁浅率急剧增加，因此，广泛的有关识别免疫系统细胞的免疫系统和特异性抗体的知识，对于监测和记录鲸类健康至关重要。这项研究的目的是确定在海豚条纹藻Stenella coeruleoalba的气道，肺和相关淋巴结中以Langerin / CD207标记的树突状细胞的定位。气管，支气管，肺和与肺相关的淋巴结的样本是从一名顽固的蓝藻门ten（Stenella coeruleoalba）成年男性中获得的。我们的研究结果表明，蓝藻中的肺中存在大量的淋巴样聚集物（LA）。朗格汉斯样树突状细胞沿呼吸道上皮和间质以及相关淋巴结分布良好。本研究加深了关于鲸类免疫系统的知识，并报道了关于鲸类物种的商业抗体（Langerin / CD207）的可利用性。