Synaptic transmission relies on rapid calcium (Ca2+) influx into presynaptic terminal via voltage-gated Ca2+ channels. However, smooth ER is present in presynaptic terminals and accumulating evidence indicate that ER Ca2+ signaling may play a modulatory role in synaptic transmission. Most recent publication by Lindhout and colleagues (EMBO J, 38 (2019) e101345) suggested that the fragmentation state of the ER affects synaptic vesicle release. Here we discuss these results as well as several key publications that addressed a connection between ER Ca2+ signaling and synaptic transmission.

中文翻译：

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突触前内质网和神经传递。

突触传递依赖于钙离子（Ca2 +）通过电压门控的Ca2 +通道快速流入突触前末端。然而，在突触前末端存在平滑的ER，并且越来越多的证据表明ER Ca2 +信号传导可能在突触传递中起调节作用。Lindhout及其同事的最新出版物（EMBO J，38（2019）e101345）建议ER的片段化状态影响突触小泡的释放。在这里，我们讨论这些结果以及解决ER Ca2 +信号传导与突触传递之间联系的一些关键出版物。