A practical catalytic asymmetric benzylic C(sp³)–H amination through the intermolecular insertion of a rhodium-bound nitrene species is reported. The reaction of various substrates (used as the limiting component) with the readily accessible sulfamate PfbsNH₂ and the chiral rhodium(II) catalyst Rh₂(S-tfptad)₄ in the presence PhI(OPiv)₂ can be performed on a multigram scale, affording the corresponding benzylic amines with high levels of efficiency and enantiocontrol. This process offers new opportunities for the asymmetric synthesis of amines.

中文翻译：

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氨基磺酸酯催化分子间C（sp ³）-H胺的不对称合成

据报道，通过分子间插入铑键合的氮原子，可实现催化不对称的苄基C（sp ³）-H胺化反应。在存在PhI（OPiv）₂的情况下，各种底物（用作限制组分）与易于获得的氨基磺酸盐PfbsNH ₂和手性铑（II）催化剂Rh ₂（S -tfptad）₄的反应可以以克数进行。 ，从而提供相应的苄基胺，且具有较高的效率和对映体控制能力。该方法为胺的不对称合成提供了新的机会。