Background

In this study, risk factors for loco-regional recurrence in curative R0 resected gallbladder adenocarcinoma were investigated.

Methods

Patients with gallbladder adenocarcinoma with curative R0 resections between 2000 and 2016 were retrospectively reviewed. Loco-regional failure-free survival (LRFFS) and overall survival (OS) were analyzed using the Kaplan–Meier method; prognostic factors were analyzed using the Cox proportional hazards model. Based on the identified risk factors, patients were grouped for further analysis.

Results

A total of 272 patients were included for analysis; overall, 5-year LRFFS and OS were 83% and 81%, respectively. On multivariate analysis, 3 risk factors for LRFFS were identified; lymphovascular invasion, T3, and N1, by which patients were grouped; group 1 for 0 factor, group 2 for 1 factor and group 3 for 2 to 3 factors. The 5-year LRFFS in groups 1, 2, and 3 were 94%, 73%, and 40%, and the 5-year OS in groups 1, 2, and 3 were 90%, 75%, and 47%, respectively. LRFFS and OS differed significantly among groups (p < 0.05).

Conclusion

In patients with R0 resected gallbladder cancer, the presence of >1 risk factor increased the risk of loco-regional recurrence. Additional therapeutic strategy for these patients needs further consideration.

中文翻译：

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R0 切除胆囊癌患者的预后因素和局部区域失败模式。

背景

在这项研究中，研究了治愈性 R0 切除胆囊腺癌局部复发的危险因素。

方法

回顾性分析了 2000 年至 2016 年间接受治愈性 R0 切除术的胆囊腺癌患者。使用 Kaplan-Meier 方法分析局部区域无失败生存 (LRFFS) 和总生存 (OS)；使用Cox比例风险模型分析预后因素。根据确定的危险因素，将患者分组进行进一步分析。

结果

共纳入 272 名患者进行分析；总体而言，5 年 LRFFS 和 OS 分别为 83% 和 81%。在多变量分析中，确定了 LRFFS 的 3 个危险因素；淋巴血管侵犯、T3 和 N1，按患者分组；第 1 组为 0 个因素，第 2 组为 1 个因素，第 3 组为 2 到 3 个因素。第 1、2 和 3 组的 5 年 LRFFS 分别为 94%、73% 和 40%，第 1、2 和 3 组的 5 年 OS 分别为 90%、75% 和 47% . LRFFS 和 OS 在各组之间存在显着差异（p < 0.05）。

结论

在 R0 切除的胆囊癌患者中，>1 个危险因素的存在增加了局部区域复发的风险。这些患者的其他治疗策略需要进一步考虑。