The rapid and sensitive determination of riboflavin (RF) is important for the treatment of seborrheic and glossitis dermatitis, sunlight sensitivity, mucosal, and skin disorders. In this work, an electrochemical sensor was developed by electrodes modification using poly (chitosan) to sensitive detection of RF in commercial multivitamin. Electrodeposition of chitosan on the surface of glass carbon electrode was performed using cyclic voltammetry technique in the range of -1 to +1 V. The modified electrode surface morphology was characterized using a high-resolution field emission scanning electron microscope. The modified electrode was used as an effective electrical interface for the detection of RF using cyclic, differential pulse, and square wave voltammetry techniques. Finally, the sensor was applied to determine RF in commercial multivitamins. In optimum conditions, the linear range for the standard sample of RF and commercial multivitamins 94 to 333μM and 24.6 to 176μM were obtained, respectively. Low limit of quantification (LLOQ) were obtained as 24.6μM.

中文翻译：

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使用基于聚（壳聚糖）的纳米复合材料灵敏监测商业多种维生素中的核黄素。

快速而灵敏的核黄素（RF）测定对于脂溢性和舌炎性皮炎，日光敏感性，粘膜和皮肤疾病的治疗很重要。在这项工作中，通过使用聚（壳聚糖）对电极进行修饰来开发电化学传感器，以灵敏地检测商用复合维生素中的RF。使用循环伏安法在-1至+1 V范围内在玻璃碳电极表面进行壳聚糖的电沉积。使用高分辨率场发射扫描电子显微镜对修饰的电极表面形态进行表征。使用循环，差分脉冲和方波伏安法技术，将修饰的电极用作检测RF的有效电接口。最后，该传感器被用于测定商业复合维生素中的RF。在最佳条件下，RF和商用多种维生素标准样品的线性范围分别为94至333μM和24.6至176μM。定量下限（LLOQ）为24.6μM。