Communication between cells is an important, evolutionarily conserved mechanism which enables the coordinated function of multicellular organisms. Heterogeneity within cell populations drive a remarkable network of cellular cross-talk that allows the heart to function as an integrated unit with distinct tasks allocated to sub-specialized cells. During diseases and aging, cells acquire an overt disordered state that significantly contributes to an altered cellular cross-talk and hence drive cardiac remodeling processes and cardiovascular diseases. However, adaptive mechanisms, and phenotypic changes in subpopulations of cells (e.g. reparative macrophages or fibroblasts) can also contribute to repair and regeneration. In this article, we review the cellular cross-talks between immune cells, endothelial cells, fibroblasts and cardiomyocytes that control heart failure by contributing to cardiac dysfunction and aging, or by mediating repair and regeneration of the heart after injury.

中文翻译：

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患病和衰老的心脏中的细胞串扰。

细胞之间的通讯是一种重要的，进化上保守的机制，可实现多细胞生物的协调功能。细胞群内的异质性驱动了一个非凡的细胞串扰网络，使心脏可以作为整合单元发挥功能，并为子专业细胞分配不同的任务。在疾病和衰老过程中，细胞会出现明显的无序状态，这显着促进了细胞串扰的改变，从而驱动了心脏重塑过程和心血管疾病。但是，适应性机制以及细胞亚群（例如修复性巨噬细胞或成纤维细胞）的表型变化也可能有助于修复和再生。在本文中，我们回顾了免疫细胞，内皮细胞之间的细胞串扰，