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Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.
Journal of Histochemistry & Cytochemistry ( IF 3.2 ) Pub Date : 2019-10-22 , DOI: 10.1369/0022155419885112
Yong Wan 1 , Casey White 1 , Nadine Robert 1 , Matthew B Rogers 2 , Heather L Szabo-Rogers 1, 3, 4
Affiliation  

Optic development involves sequential interactions between several different tissue types, including the overlying ectoderm, adjacent mesoderm, and neural crest mesenchyme and the neuroectoderm. In an ongoing expression screen, we identified that Tfap2β, Casq2, Penk, Zic1, and Zic3 are expressed in unique cell types in and around the developing eye. Tfap2β, Zic1, and Zic3 are transcription factors, Casq2 is a calcium binding protein and Penk is a neurotransmitter. Tfap2β, Zic1, and Zic3 have reported roles in brain and craniofacial development, while Casq2 and Penk have unknown roles. These five genes are expressed in the major tissue types in the eye, including the muscles, nerves, cornea, and sclera. Penk expression is found in the sclera and perichondrium. At E12.5 and E15.5, the extra-ocular muscles express Casq2, the entire neural retina expresses Zic1, and Zic3 is expressed in the optic disk and lip of the optic cup. The expression of Tfap2β expanded from corneal epithelium to the neural retina between E12.5 to E15.5. These genes are expressed in similar domains as Hedgehog (Gli1, and Ptch1) and the Wnt (Lef1) pathways. The expression patterns of these five genes warrant further study to determine their role in eye morphogenesis:



中文翻译:

Tfap2β,Casq2,Penk,Zic1和Zic3表达在胚胎小鼠眼的视网膜,肌肉和巩膜中的定位。

视神经发育涉及几种不同组织类型之间的顺序相互作用,包括上覆外胚层,相邻中胚层,神经neural间充质和神经外胚层。在一个正在进行的表达筛选,我们确定了Tfap2βCASQ2PENKZIC1Zic3在和周围的发展眼光独特的细胞类型中表达。Tfap2βZIC1Zic3是转录因子,CASQ2是钙结合蛋白和PENK是一种神经递质。Tfap2βZic1Zic3在大脑和颅面发展报告的作用,而CASQ2PENK有未知的角色。这五个基因在眼睛的主要组织类型中表达,包括肌肉,神经,角膜和巩膜。在巩膜和软骨膜中发现了Penk表达。在E12.5和E15.5时,眼外肌表达Casq2,整个神经视网膜表达Zic1,而Zic3在视盘和视杯的唇中表达。Tfap2β的表达从角膜上皮扩展到E12.5至E15.5之间的神经视网膜。这些基因在与刺猬(Gli1Ptch1)和Wnt(Lef1)途径。这五个基因的表达模式值得进一步研究,以确定它们在眼部形态发生中的作用:

更新日期:2020-04-21
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