Asperpentenone A (1), a novel polyketide with a rare cyclopentenone-tetrahydrofuran moiety, was isolated along with eight known compounds (2–9) from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and X-ray crystallography. Biological evaluation results revealed that kojic acid (3) showed weak antibacterial activities against Bacillus thuringiensis and Acinetobacter baumannii with MIC values of 32 and 128 μg/mL, respectively. Furthermore, griseofamine A (9) exhibited weak antibacterial activity with an MIC value of 64 μg/mL against Escherichia coli. The results of antibacterial experiments and especially the large yield of kojic acid (3) indicated that kojic acid might represent a candidate precursor for the development of antimicrobial agents.

Asperpentenone A（1），一种新型聚酮化合物与一种罕见的环戊烯酮-四氢呋喃基部分，用8种已知化合物（沿分离2 - 9衍生自真菌深海）曲霉属。SCSIO41024。通过对其光谱分析和X射线晶体学的广泛分析，确定了包括绝对构型在内的结构。生物学评估结果表明，曲酸（3）对苏云金芽孢杆菌和鲍曼不动杆菌具有较弱的抗菌活性，MIC值分别为32和128μg / mL。此外，灰黄胺A（9）表现出弱的抗菌活性，对大肠杆菌的MIC值为64μg / mL 。抗菌实验的结果，尤其是曲酸的高收率（3）表明曲酸可能代表了开发抗菌剂的候选前体。