In this paper, we propose a mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative to treatment of a glioma. The main idea is to incorporate the virotherapy after the first or second chemotherapy session using a specialist virus that attacks only tumor cells. Some simulations are presented. Based on the results, we conclude that with this combined therapy may reduce the number of chemotherapy sessions and may lead to obtain better results in the fight against gliomas.

中文翻译：

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结合化疗和溶瘤病毒疗法作为治疗胶质瘤的替代疗法的数学模型

在本文中，我们提出了一种数学模型，该模型将化学疗法和溶瘤病毒疗法相结合，作为治疗胶质瘤的替代方法。主要想法是在第一次或第二次化疗后使用仅攻击肿瘤细胞的专科病毒进行病毒疗法。给出了一些模拟。根据结果​​，我们得出结论，采用这种联合疗法可能会减少化疗次数，并可能在对抗胶质瘤方面取得更好的效果。