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Comparison with randomized controlled trials as a strategy for evaluating instruments in Mendelian randomization
International Journal of Epidemiology ( IF 7.7 ) Pub Date : 2019-11-25 , DOI: 10.1093/ije/dyz236
Dipender Gill 1 , Venexia M Walker 2, 3 , Richard M Martin 2, 3 , Neil M Davies 2, 3 , Ioanna Tzoulaki 1, 4
Affiliation  

The Mendelian randomization (MR) approach uses genetic variants as instrumental variables to study the effect of an exposure on an outcome.1 In this way, by selecting genetic variants that serve as instrumental variables for drug effects, it can also be possible to study corresponding drug side-effects and repurposing potential.2 Such an approach has recently been applied to antihypertensive drugs by two separate research groups independently of each other.3,4 Here, the authors of these two papers collaboratively discuss a strategy that can be used for validating instruments for such study.

中文翻译:

与随机对照试验比较作为评估孟德尔随机化工具的策略

孟德尔随机化 (MR) 方法使用遗传变异作为工具变量来研究暴露对结果的影响。1通过这种方式,通过选择作为药物作用工具变量的遗传变异,还可以研究相应的药物副作用和再利用潜力。2这种方法最近被两个相互独立的研究小组应用于抗高血压药物。3 , 4在这里,这两篇论文的作者共同讨论了一种可用于验证此类研究工具的策略。
更新日期:2019-11-25
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