Extracellular matrix (ECM) macromolecules together with a multitude of different molecules residing in the extracellular space play a vital role in the regulation of cellular phenotype and behavior. This is achieved via constant reciprocal interactions between the molecules of the ECM and the cells. The ECM-cell interactions are mediated via cell surface receptors either directly or indirectly with co-operative molecules. The ECM is also under perpetual remodeling process influencing cell-signaling pathways on its part. The fragmentation of ECM macromolecules provides even further complexity for the intricate environment of the cells. However, as long as the interactions between the ECM and the cells are in balance, the health of the body is retained. Alternatively, any dysregulation in these interactions can lead to pathological processes and finally to various diseases. Thus, therapeutic applications that are based on retaining normal ECM-cell interactions are highly rationale. Moreover, in the light of the current knowledge, also concurrent multi-targeting of the complex ECM-cell interactions is required for potent pharmacotherapies to be developed in the future.

中文翻译：

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细胞外基质与细胞的相互作用：专注于治疗应用。

细胞外基质（ECM）大分子与细胞外空间中的许多不同分子一起在调节细胞表型和行为中起着至关重要的作用。这是通过ECM分子与细胞之间不断的相互作用而实现的。ECM细胞相互作用是通过细胞表面受体直接或间接地与合作分子介导的。ECM也处于永久性重塑过程中，从而影响其细胞信号通路。ECM大分子的片段化为细胞的复杂环境提供了进一步的复杂性。但是，只要ECM与细胞之间的相互作用达到平衡，就可以保持身体的健康。或者，这些相互作用中的任何失调都可能导致病理过程，最终导致各种疾病。因此，基于保持正常ECM-细胞相互作用的治疗应用是高度合理的。而且，根据当前的知识，复杂的ECM-细胞相互作用的同时多目标化对于将来开发有效的药物治疗也是必需的。